Under constant light illumination, cortical neuronal activity slightly modulates intensity of the light reflected from cortical surface. Optical imaging of the reflected light from the cortex has now become a popular method to obtain cortical functional maps. Since the modulation signal is small, this method is very sensitive to other sources of the light intensity changes. A well-known artifac...

Computational ghost imaging (CGI) enables an image to be recorded using a single-pixel detector. The image can be reconstructed from correlations between the scene and a series of known projected intensity patterns. In this work we investigate the performance of CGI using pseudo non-diffracting (ND) speckle patterns. We demonstrate an extended depth-of-field that is ∼ 2-3 times greater than tha...

The human face is an array of variable physical features that together make each of us unique and distinguishable. Striking familial facial similarities underscore a genetic component, but little is known of the genes that underlie facial shape differences. Numerous studies have estimated facial shape heritability using various methods. Here, we used advanced three-dimensional imaging technolog...

Recently, we have proposed a method to image fluorescent structures behind turbid layers at diffraction limited resolution using wave-front shaping and the memory effect. However, this was limited to a raster scanning of the wave-front shaped focus to a two dimensional plane. In applications, it can however be of great importance to be able to scan a three dimensional volume. Here we show that ...

TCRT special section focusing on four articles to advance optical imaging which focuses on the prostate, breast, and fluorescence tumor markers for less invasive cancer diagnosis using light. Some of the articles touch upon the use of hypoxia in cancer tumors are discussed as a native bio marker advancing the ideas of Nobel Laureate Otto Warburg postulated in 1924, commonly called the Warburg e...

A computer model of a patient-specific clinical (177)Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of (177)Lu-DOTATATE are used. Aspects included in the dosimetry-process model are t...

The possibilities of using laser-induced fluorescence for tissue diagnostics are discussed. The tissue types investigated are malignant tumors and atherosclerotic lesions. Studies with natural autofluorescence as well as with fluorescent tumor markers are included in this paper. Fluorescence emission and decay data are presented for some tissue chromophores contributing to tissue autofluorescen...

The emerging technique of magnetic resonance force microscopy (MRFM) (Sidles, 1991) was conceived by Sidles (1992) as a tool that could provide the revolutionary capability for three-dimensional imaging of single-copy biomolecules. This challenging goal has been augmented by a growing interest in applying it to imaging, especially subsurface imaging, of a broad range of materials and devices in...

to the editor: Zile et al. (May 6 issue) 1 conclude that heart failure develops in patients with a normal ejection fraction because of abnormal active and passive diastolic function. However, the applicability of this conclusion to all such patients is uncertain for several reasons. First, accurate assessment of left ventricular volume, on which the conclusions critically depend, requires a thr...

Digital technology is progressively changing our vision of the practice of neuropathology. There are a number of facts that support the introduction of digital neuropathology. With the development of wholeslide imaging (WSI) systems the difficulties involved in implementing a neuropathology network have been solved. A relevant difficulty has been image standardization, but an open digital image...