As a chemotherapeutic drug, cyclophosphamide (CP) has negative impact on male fertility due to its reproductive toxicity. Melatonin (Mel) promotes the system and increases testosterone synthesis. This study is aimed at exploring molecular mechanism of Mel as protector against CP-induced cytotoxicity. A CP toxicity model was established in adult ICR mice by intraperitoneal injection 100 mg/kg ev...

Background: IgA vasculitis (IgAV) is the most common systemic of childhood, characterized by palpable purpura, arthritis, gastrointestinal and renal involvement 1 . It a relatively self-limited disease apart from which associated with long term morbidity. Objectives: We aimed to define marker at onset predict involvement. Methods: In this pilot study, we analyzed targeted panel vascular inflamm...

Abstract Gene–diet interactions may play an important role in the inter individual diversity observed on cardiovascular disease (CVD) risk factors. Therefore, current study, we examined interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII DIL), altering CVD factors among type 2 diabetes mellitus (T2DM). In this cross-sectional blood samples were collected from 220 dia...

Amaç: Vitiligo, fonksiyonel melanositlerin kaybı ile karakterize yaygın bir pigment bozukluğudur. İmmünopatogenezi tam olarak aydınlatılamasa da cilt mikroçevresindeki inflamatuar değişikliklerin ve özellikle sitokin ekspresyonunun artmasının, melanosit disfonksiyonu ölümünün temel nedeni olduğu düşünülmektedir. Vitiligonun IFN-γ inhibisyonu kullanılarak tedavisi pozitif sonuçlar elde edilmişti...