Different methods are used to assess the vasodilator ability of cerebral blood vessels; however, the exact mechanism of cerebral vasodilation, induced by different stimuli, is not entirely known. Our aim was to investigate whether the potent vasodilator agent, acetazolamide (AZ), inhibits the neurovascular coupling, which also requires vasodilation. Therefore, visually evoked flow parameters we...

This paper explores the usage of the area (Az) under the Receiver Operating Characteristic (ROC) curve as error measure to guide the training process to build machine learning ANN-based classifiers for biomedical data analysis. Error measures (like root mean square error, RMS) are used to guide training algorithms measuring how far solutions are from the ideal classification, whereas it is well...

The ATPase activities of Hsp70 and Hsc70 are known to be responsible for regulation of various biological processes. However, little is known about the roles of Hsp70 and Hsc70 in modulation of immune responses to antigens. In the present study, we investigated the effect of apoptozole (Az), a small molecule inhibitor of Hsp70 and Hsc70, on immune responses to protein antigens. The results show...

TO THE EDITOR: We followed with great interest the recent exchanges between Drs. Teppema and Berendsen (4) on one hand and Dr. Swenson on the other hand regarding the mechanisms of effects of acetazolamide (AZ) in the prevention of Acute Mountain Sickness (AMS) (3). One of the essential questions raised by both parts is the action of AZ on central and peripheral chemosensitivity, respectively. ...

Assessing the relative efficiency of energy use among similar manufacturing industries Fernando Aguirre, J. Rene Villalobos , Patrick E. Phelan and Rafael Pacheco US Airways, AZ 85281, U.S.A. International Logistics and Productivity Improvement Laboratory, School of Computing, Informatics and Decisions Systems Engineering, Arizona State University, Tempe, AZ 85287-8809, U.S.A. School of Mechani...

Kandis Lea Jessup, Lowell Observatory, 1400 W Mars Hill Rd, Flagstaff, AZ, 86001 John R. Spencer, Lowell Observatory, 1400 W Mars Hill Rd, Flagstaff, AZ, 86001 Gilda E. Ballester, Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85271 Robert R. Howell, Dept. Geology and Geophysics, University of Wyoming, Laramie, WY 82071 Fred Roesler, Department of Physics, University of Wisco...

Morbidity Associated with False-Positive Findings in Post-Treatment Positron Emission Tomography/Computed Tomography in Chemoradiation Treated Head and Neck Cancer Patients Sun K. Yi, M.D., Sarah Kratz, M.D., TJ Gernon, M.D., Audrey Erman, M.D., Rihan Khan, M.D., Ryan Avery, M.D., Fatima Aly, M.D., Phillip H. Kuo, M.D., Ph.D., Michael K. Cheung, M.D., Georgi Georgiev, M.S. 1Department of Radiat...

Synaptic vesicles fuse at active zone (AZ) membranes where Ca(2+) channels are clustered and that are typically decorated by electron-dense projections. Recently, mutants of the Drosophila melanogaster ERC/CAST family protein Bruchpilot (BRP) were shown to lack dense projections (T-bars) and to suffer from Ca(2+) channel-clustering defects. In this study, we used high resolution light microscop...

The role of antizyme (AZ) and glycosaminoglycans in polyamine uptake by mammalian cells and mitochondria was examined using NIH3T3 and FM3A cells and rat liver mitochondria. AZ is synthesized as two isoforms (29 and 24.5 kDa) due to the existence of two initiation codon AUGs in the AZ mRNA. Most AZ existed as the 24.5-kDa form translatable from the second AUG, but a portion of the 29-kDa AZ fro...

Polyamines are small aliphatic polycations present in all living cells. Polyamines are essential for cellular viability and are involved in regulating fundamental cellular processes, most notably cellular growth and proliferation. Being such central regulators of fundamental cellular functions, the intracellular polyamine concentration is tightly regulated at the levels of synthesis, uptake, ex...