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Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease. The etiology and treatment options of IGM remain controversial. Previous case reports have suggested that hyperprolactinemia may be associated with IGM. In the present report, we describe the first case of IGM associated with risperidone-induced hyperprolactinemia.
Secreted IgM was shown to contain truncated mu (mu') chains with an apparent molecular mass of approximately 55 kD. The estimated percentage of IgM heavy (H) chains in the mu' form ranged from less than or equal to 1% in the case of one tumor IgM protein (104E) to greater than or equal to 30% in normal serum IgM. Serum mu' chains lacked antigenic determinants characteristic of immunoglobulin va...
Five meta-analyses and 18 RCTs were considered, including 12 trials studied the effect of IgM in adults [1-12], 5 in newborns [13-17], and one in children 1-24 months old [18]. All interventions were applied with basic therapy (BT). No difference between IgM and albumin was found for adults (Fig.1). However we found significant efficacy of IgM in adults when compared with all comparators, RR 0....
Background & Aim: Toxoplasmosis is a common disease between human and animal with an extensive distribution. It is caused by the parasitical protozoan Toxoplasma gondii. Most clinical laboratories have problems with the diagnosis of toxoplasmosis. The aim of this study is the comparison of sensitivity and specificity of conventional and unconventional methods in the diagnosis of Toxoplasmos...
approved WNV IgM tests, we were concerned that this phenomenon might also occur with new tests. Thus in 2004, we initiated a follow-up study of patients infected during the inaugural (2003) WNV season in Alberta, Canada. Fifty patients who were WNV IgM positive by 2 commercial IgM kits (West Nile virus capture EIAs, Focus Technologies, Cypress, CA, USA, and Panbio, Windsor, Queensland, Australi...
From paired blood and spleen samples from three adult donors, we performed high-throughput VH sequencing of human B cell subsets defined by IgD and CD27 expression: IgD(+)CD27(+) ("marginal zone [MZ]"), IgD(-)CD27(+) ("memory," including IgM ["IgM-only"], IgG and IgA) and IgD(-)CD27(-) cells ("double-negative," including IgM, IgG, and IgA). A total of 91,294 unique sequences clustered in 42,670...
BACKGROUND Antibodies are often involved in enhancing particle clearance by macrophages. Although the mechanisms of antibody-dependent phagocytosis have been studied for IgG in greater detail, very little is known about IgM-mediated clearance. It has been generally considered that IgM does not support phagocytosis. Recent studies indicate that natural IgM is important to clear microbes and othe...
IgM provides a first line of defense during microbial infections. Serum IgM levels are detected routinely in clinical practice. And IgM is a genetically complex trait. We conducted a two-stage genome-wide association study (GWAS) to identify genetic variants affecting serum IgM levels in a Chinese population of 3495, including 1999 unrelated subjects in the first stage and 1496 independent indi...
Diagnosis of Mycoplasma pneumoniae infection is important due to its variable clinical manifestations and absence of response to beta-lactams. Introduction of enzyme immunoassays (EIAs) for serologic diagnosis of M. pneumoniae has made it possible to separate the analyses of specific IgG and IgM antibodies. We compared four different commercial EIAs, ImmunoWELL IgG, IgM (GenBio), Medac IgG, IgA...
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