Background The peach Lipid Transfer Protein (LTP), Pru p 3, is considered to be a major allergen in peach allergy, but sensitization to it is almost always present in LTP-syndrome. Thus, detection of Pru p 3 specific IgE (sIgE) is frequent in routine peach and/or LTP allergy diagnosis. ImmunoCAP is one of the most frequent immunoassays for specific IgE detection, with a 0.1kU/L detection limit,...

Hyper-immunoglobulin E syndromes (HIES) including compound primary immunodeficiency and nonimmunological abnormalities are characterized by extremely high serum IgE levels, eosinophilia, eczema, susceptibility to infections, distinctive facial appearance, retention of deciduous teeth, cyst-forming pneumonias, and skeletal abnormalities. Itis reported that some cases of familial HIES are relativ...

We report the first case of cefepime-induced "red-man syndrome," which appeared 30 min following drug infusion and was confirmed with a rechallenge test. This syndrome is classically associated with vancomycin infusion and is the result of non-IgE mediated mast cell degranulation. While this adverse effect can be easily managed with drug withdrawal and antihistamine administration, it is unknow...

The myriad genetic associations with idiopathic (primary) generalized epilepsies (IGE) are challenging to both researchers and caregivers. There are numerous mutations, among them voltagegated sodium, potassium, and calcium channels and ligand-gated GABA receptors. A variety of mutations may produce similar phenotypes, while, equally troublesome, single mutations may produce a range of phenotyp...

Occupational asthma has become the most prevalent occupational lung disease in developed countries. At present, about 200 agents have been implicated in causing occupational asthma in the workplace. These agents can be divided into two categories by their mechanism of action: immunological and nonimmunological. Immunological causes can be further divided into those that induce asthma through an...

Phosphoglucomutase 3 (PGM3) is an enzyme converting N-acetyl-glucosamine-6-phosphate to N-acetyl-glucosamine-1-phosphate, a precursor important for glycosylation. Mutations in the PGM3 gene have recently been identified as the cause of novel primary immunodeficiency with a hyper-IgE like syndrome. Here we report the occurrence of a homozygous mutation in the PGM3 gene in a family with immunodef...

Hyper-IgE syndrome (HIES) is characterized by recurrent skin and pulmonary infections (mainly bacterial), eczematous dermatitis and elevated serum IgE levels. Associated abnormalities in some patients include coarse facial features, failure or delay of shedding of primary teeth, recurrent fractures, hyperextensible joints, and scoliosis. Laboratory abnormalities include elevated total serum IgE...

Objective The study aim was to compare interictal encephalographic (EEG) functional network topology between people with well-controlled idiopathic generalized epilepsy (WC-IGE) and drug-resistant IGE (DR-IGE). Methods Nineteen participants WC-IGE, 18 DR-IGE, 20 controls underwent a resting state, 64-channel EEG. An artifact-free epoch bandpass filtered into the frequency range of high low exte...

BACKGROUND In recent years, increased serum immunoglobulin E (IgE) concentration in patients with cardiovascular diseases has been generating more and more interest. It is as yet unknown, however, if the increased IgE level is a marker of future coronary incidents and whether it may be regarded as an ischemic heart disease risk factor, or if it is indicative of the participation of antibodies i...