Prof. Dr. Şinasi Özsoylu, Hacettepe Children’s Hospital, TR-06100 Ankara (Turkey) I have read with interest Barrios et al.’s paper on the ‘Treatment of Acute Idiopathic Thrombocytopenic Purpura with High-Dose Methylprednisolone and Immuno-globulin’ in a recent issue of the journal [1993;89:6-9]. The authors concluded that ‘the combined therapy resulted in rapid increments in the platelet counts...

Prof. Dr. Şinasi Özsoylu, Hacettepe Children’s Hospital, TR-06100 Ankara (Turkey) I have read with interest Barrios et al.’s paper on the ‘Treatment of Acute Idiopathic Thrombocytopenic Purpura with High-Dose Methylprednisolone and Immuno-globulin’ in a recent issue of the journal [1993;89:6-9]. The authors concluded that ‘the combined therapy resulted in rapid increments in the platelet counts...

background: idiopathic thrombocytopenic purpura is an autoimmune blood disorder in which platelet destruction is mediated by anti-platelet antibodies. there are two forms of itp: acute and chronic. the aim of the present study was to evaluate the clinical variables in adult patients with acute itp in west of iran. patients and methods: medical records of adult patients with diagnosis of acute i...

OBJECTIVE To increase our understanding of the etiology of idiopathic thrombocytopenic purpura (ITP) some cytokine gene polymorphisms were analyzed for susceptibility to the disease. The aim of this study was to investigate the role of tumor necrosis factor-alpha (TNF-α) -308 G/A and transforming growth factor-beta 1 (TGF-β1) -915 G/C polymorphisms in the development and clinical progression of...

OBJECTIVE To determine the incidence of immune thrombocytopenic purpura (ITP) after measles-mumps-rubella (MMR) immunization compared with natural measles and rubella, its clinical course and outcome, and the risk of recurrence after repeat MMR vaccination. STUDY DESIGN We performed a systematic review of the Ovid MEDLINE (1950 to present) bibliographic database. We selected studies that repo...

A 51-yr-old female was referred to our outpatient clinic for the evaluation of generalized edema. She had been diagnosed with idiopathic thrombocytopenic purpura (ITP). She had taken no medicine. Except for the ITP, she had no history of systemic disease. She was diagnosed with systemic lupus erythematosus. Immunosuppressions consisting of high-dose steroid were started. When preparing the pati...

We describe the effect on the neonate of administration of rituximab to a woman with idiopathic thrombocytopenic purpura (ITP). Rituximab, an anti-CD20 antibody, was given weekly for 4 weeks to a woman with ITP in her third trimester of pregnancy. One month after the last rituximab administration a healthy girl was born. She had normal growth and development during the first six months. At birt...