Despite the synergy of immune checkpoint blockade (ICB) therapy and photodynamic (PDT) holds great promise as countermeasures against breast cancer, exploring long-term or flexible short-time therapeutic strategies in “cold” tumors remains a challenge. Here, we present polyunsaturated fatty acid-doped liposomal hydrogel Lp(DHA)@CP Gel loaded with photosensitizer chlorin e6 (Ce6) programmed deat...

Abstract Epigenetic scarring of exhausted CD8 T (TEX) cells during chronic virus infections or cancer remains a major cell-intrinsic barrier to cell immunotherapies, including immune checkpoint blockade (ICB). For successful epigenetic reprogramming TEX cells, it is crucial identify and target the molecular mechanisms underlying terminal exhaustion. Previous work revealed that de novo DNA methy...

Despite the remarkable success and efficacy of immune checkpoint blockade (ICB) therapy against PD-1/PD-L1 axis, it induces sustained responses in a sizeable minority cancer patients due to activation immunosuppressive factors such as myeloid-derived suppressor cells (MDSCs). Inhibiting function MDSCs is critical for successful ICB therapy. Interestingly, lipid metabolism crucial factor modulat...

With the pronounced need for reliable personal identification, iris recognition has become an important enabling technology in our society. Although an iris pattern is naturally an ideal identifier, the development of a high-performance iris recognition algorithm and transferring it from research lab to practical applications is still a challenging task. Automatic iris recognition has to face u...

Shihua Chen,1,* Fabio Baronio,2 J. M. Soto-Crespo,3 Philippe Grelu,4,† Matteo Conforti,5 and Stefan Wabnitz2 1Department of Physics, Southeast University, Nanjing 211189, China 2Dipartimento di Ingegneria dell’Informazione, Università di Brescia, Via Branze 38, 25123 Brescia, Italy 3Instituto de Óptica, Consejo Superior de Investigaciones Cientı́ficas (CSIC), Serrano 121, Madrid 28006, Spain 4La...

Correspondence to: Mario J Avila-Campos Laboratório de Anaeróbios Departamento de Microbiologia ICB/ USP Av. Prof. Lineu Prestes, 1374 05508-900 São Paulo, SP, Brasil E-mail: [email protected] Partially financied by Fundação de Amparo à Pesquisa do Estado de São Paulo (Fapesp Process n. 00/07785-3 and 00/ 07582-5). Based on thesis presented to Departamento de Microbiologia, Instituto de Ciências ...

Background Immune checkpoint blockade (ICB) is a clinically proven concept to treat cancer. Still, majority of cancer patients including those with poorly immune infiltrated “cold” tumors are resistant currently available ICB therapies. CTLA-4 one few validated targets for ICB, but toxicities linked efficacy in approved anti-CTLA-4 regimens have restricted their use and precluded full therapeut...

It is shown how ab initio techniques based on density functional theory can be used to calculate the chemical potentials of the leading candidate impurity elements (S, O and Si) in the Earth's solid inner core and liquid outer core. The condition that these chemical potentials be equal in the solid and liquid phases provides values for the ratios of the impurity mol fractions in the inner and o...

We constrain seismic properties of the inner core using various body wave observations. In the epicentral distance range of 10−70 o , our high quality measurements of the amplitude ratio of PKiKP and PcP provide a new estimate of the density contrast (0.6-0.9 g/cm 3) at the Inner Core Boundary (ICB). This estimate is compatible with a recent reevaluation of normal mode data, and thus reconciles...