We report the case of a 72-year-old woman diagnosed with ostium secundum atrial septal defect (OS-ASD) in an echocardiogram performed as part of the work-up for her high blood pressure. Over time, progressive dilation of the right ventricle was observed with progressive functional deterioration, indicating closure of the defect. Transesophageal echocardiography (TEE) confirmed an OS-ASD of 15×1...

Background Osteoarthritis (OA) is a common chronic degenerative disease caused by progressive cartilage degradation [1]. In OA, regenerative medicine based on mesenchymal stem cells (MSCs) considered the most promising method for restoring articular [2]. However, high heterogeneity of MSCs together with invasive and painful procedures cell isolation represent main challenges tissue engineering ...

TOPIC: Chest Infections TYPE: Medical Student/Resident Case Reports INTRODUCTION: A short course intrapleural instillation of tissue plasminogen activator (tPA) and recombinant human deoxyribonuclease I (dornase alfa) is a highly safe effective treatment for complicated parapneumonic effusions (CPE) empyema. It improves drainage reduces surgical referral as well hospitalization length [1-3]. Cl...

Transcatheter valvular interventions provide symptomatic patients with minimally invasive treatment options, often without the need for general anesthesia (GA) or transesophageal echocardiography (TEE). However, mitral transcatheter edge-to-edge repair (TEER) is still performed almost exclusively GA and TEE, requiring both endotracheal esophageal intubation, which increase procedural risk may b...

BACKGROUND Our objective was to examine the accuracy of intracardiac ultrasound (ICUS) measurement of left ventricular (LV) volumes and ejection fraction (EF) using a 10-MHz ultrasound catheter. ICUS can image the LV in cross sections at all levels along the long axis with a transducer mounted on the tip of a catheter. Sequential serial LV cross-sectional images can be obtained during cardiac c...

To the Editor: Paredes et al1,2 showed, in a manuscript published recently in Science, that human postnatal neurogenesis occurs in noncanonical niches in the frontal lobe and that immature interneurons migrate long distances even in the postmortem brain. These immature interneurons are likely to be postmitotic neurons born principally in the medial ganglionic eminence (MGE; Figure A).1,3,4 The ...

The significance of knowledge in organizations is evident. There is considerable effort in theory as well as in practice on how to foster knowledge as a resource in organizations (see for example Grant, 1996, Tsoukas, 1996). In comparison with traditional resources, knowledge, especially the tacit dimension, differs because of its immaterial characteristics (concerning the concept of tacit know...

Introduction Many previous studies have observed atrophy and abnormal water diffusivity within the corpus callosum (CC) of multiple sclerosis (MS) patients [1, 2]. However, few studies have addressed the question whether such abnormalities exist in the earlier stages of MS, especially in clinically isolated syndrome (CIS). In this study, we aimed to investigate CC abnormalities in CIS patients ...

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