Inhibition of xenobiotic-metabolizing enzymes by metals may represent an important mechanism in regulating enzyme activity. Fourteen cations were evaluated for inhibition of microsomal epoxide hydrolase (mEH) (mouse, rat, and human liver), soluble epoxide hydrolase (sEH) (mouse, rat, and human liver), and recombinant potato sEH. Of the metals tested, Hg2+ and Zn2+ were the strongest inhibitors ...

BACKGROUND Randomized controlled trials (RCT) are limited by their generalizability to the broader nontrial population. To provide a context for Acute Study of Nesiritide in Decompensated Heart Failure (ASCEND-HF) trial, we designed a complementary registry to characterize clinical characteristics, practice patterns, and in-hospital outcomes of acute heart failure patients. METHODS AND RESULT...

Membrane transport pathways for transplacental transfer of CO2/HCO3 were investigated by assessing the possible presence of a Cl/HCO3 exchange mechanism in the maternal-facing membrane of human placental epithelial cells. Cl/HCO3 exchange was tested for in preparations of purified brush border membrane vesicles by 36Cl tracer flux measurements and determinations of acridine orange fluorescence ...

The present review will consider nutritional support problems in acute renal failure (ARF) and chronic renal failure (CRF) patients, chronic ambulatory peritoneal dialysis (CAPD) and those receiving regular haemodialysis (HD) treatment. For many years little advance had been made in the nutritional management of ARF until it was understood that such patients should receive protein and adequate ...

The measurement of metabolites constitutes a useful tool for detection of exposure and in pharmacokinetic studies. Epoxidation with subsequent glutathione conjugation and mercapturic acid formation is an important deactivation pathway for naphthalene, a toxin which presumably causes lung disease. The mercapturic acid conjugates of naphthalene [NaphMA (1), N-acetyl-S-(1,2-dihydro-1-hydroxy-2-nap...

PEPC [PEP (phosphoenolpyruvate) carboxylase] is a tightly controlled anaplerotic enzyme situated at a pivotal branch point of plant carbohydrate metabolism. Two distinct oligomeric PEPC classes were discovered in developing COS (castor oil seeds). Class-1 PEPC is a typical homotetramer of 107 kDa PTPC (plant-type PEPC) subunits, whereas the novel 910-kDa Class-2 PEPC hetero-octamer arises from ...

In this article I give some impressions of the actual treatment of people in the Soviet Union in health and in disease, basing it to a fair degree on notes made during a visit to Russia in the late summer of I939. In Britain we are justly proud of the farreaching developments in the prevention and treatment of disease which have taken place in the last I50 years. The development of industry and...

Calcium binding to sarcolemma-enriched preparations from canine ventricle was evaluated. The preparation was exposed to calcium and 45Ca at physiological ionic strength, pH 7.4, for 15-18 hours at 5 degrees C. Bound calcium was separated from free by filtration and washing of the filter with solutions containing calcium and LaCl3. After equilibration at 5 degrees C, exposure to 37 degrees C cau...

Pulmonary extravascular fluid volume was measured in 64 patients with ischaemic heart disease at the time of cardiac catheterization using a double indicator dilution technique. In 3I of these patients exercise studies were done. Left ventricular and selective coronary angiography was performed in 43 and the angiographic severity of left ventricular dysfunction and of coronary artery obstructiv...

Refat Abdel-Basset and Klaus P. Bader Lehrstuhl für Zellphysiologie, Fakultät für Biologie, Universität Bielefeld, Postfach 10 01 31, D-33501 Bielefeld, Germany Z. Naturforsch. 52c, 775-781 (1997); received September 8/October 17, 1997 Photosynthesis, Mass Spectrometry, Hydrogen Photoevolution, Cyanobacterium The filamentous non-heterocystous cyanobacterium Oscillatoria chalybea is capable to p...