PURPOSE To calculate organ S values (mGy∕Bq-s) and effective doses per time-integrated activity (mSv∕Bq-s) for pediatric and adult family members exposed to an adult male or female patient treated with I-131 using a series of hybrid computational phantoms coupled with a Monte Carlo radiation transport technique. METHODS A series of pediatric and adult hybrid computational phantoms were employ...

BACKGROUND: Recently, radiopharmaceutical scanning with Tc-99m-MIBI was reported to depict areas with active bone disease in multiple myeloma (MM) with both high sensitivity and specificity. This observation was explained by the uptake of Tc-99m-MIBI by neoplastic cells. The present investigation evaluates whether Tc-99m-MIBI imaging and magnetic resonance imaging (MRI) perform equally well in ...

This study sought to evaluate the impact of multiple negative charges on blood clearance kinetics and biodistribution properties of (99m)Tc-labeled RGD peptide dimers. Bioconjugates HYNIC-P6G-RGD2 and HYNIC-P6D-RGD2 were prepared by reacting P6G-RGD2 and P6D-RGD2, respectively, with excess HYNIC-OSu in the presence of diisopropylethylamine. Their IC50 values were determined to be 31 ± 5 and 41 ...

Despite recent advances in therapeutic and diagnostic approaches, coronary artery disease (CAD) and its related cardiac disorders represent the most common cause of death in the United States. Nuclear myocardial perfusion imaging (MPI) technologies play a pivotal role in the diagnosis and treatment design for CAD. Recently, in order to develop improved MPI agents for diagnosis of CAD, (99m)Tc-[...

The diagnosis on the basis of low serum thyroxine level wiJh high thyrotropin level of congenital pri1111lfY hypothyroidism in newborn screening programs fails to distinguish between transient hypothyroidism and ectopic thyroid, athyrosis, dyshormonogenesis, or transient hyperthyrotropinemill. The correct use of neonotol thyroid scintigraphy aids in making a specific anatomic diagnosis. We scan...

amyloidosis is characterized by an abnormal extracellular deposition of amyloid in different organs, where it usually causes some type of dysfunction. its cause is unknown. five different types of amyloidosis have been described according to the underlying disease; immunoglobulin amyloidosis, familial amyloidosis, senile systemic amyloidosis, secondary amyloidosis and hemodialysis-associated am...

99mTc-octreotide scintigraphy, performed during the following up a 58-year old man with neuroendocrine tumor demonstrated massive hepatomegaly demonstrating multiple areas of increased and decreased uptake. Due to severe hepatomegaly concurrence of any other abdominal soft tissue lesions could not be excluded. A 99mTc-sulfur colloid scan was done and thoroughly compared wi...

Thyroid cancer (TC) is the commonest endocrine malignancy. In the overwhelming majority of cases, thyroid carcinomas are well-differentiated malignancies that respond favorably to treatment; however, this outcome cannot be absolutely guaranteed. The absence of large prospective randomized clinical trials in TC-due to its low incidence and protracted clinical course in cases with persistent/recu...

determination of the total body absorbed dose consists of two parts: beta radiation absorbed dose and gamma radiation absorbed dose. the first part is generally determined by clinical data, while the second part has a parameter called absorbed ratio and is determined by computational methods. the monte-carlo computational methods have been shown to be the most suitable in determination of the a...

Objective- To consider the use of renal scintigraphic evaluation of kidney function in Persian cat and make a comparison between 99mTechnetium ethylenedicysteine and 99mTechnetium diethylenetriaminepentaacetic in renal scintigraphy. Design- Descriptive study Animals- 6 male healthy adult Persian cats - no clinical sign of renal disorders and prior to presentation. Proce...