Hypoxic-ischemic encephalopathy (HIE) is the most important cause of cerebral damage and long-term neurological sequelae in the perinatal period both in term and preterm infant. Hypoxic-ischemic (H-I) injuries develop in two phases: the ischemic phase, dominated by necrotic processes, and the reperfusion phase, dominated by apoptotic processes extending beyond ischemic areas. Due to selective i...

Background Global developmental delay (GDD) is common and has a significant impact on affected children, families, society. Understanding its etiology crucial for management prevention strategies. However, data the etiological profile of GDD in developing countries are limited. This study aimed to identify at tertiary care hospital India. Methodology observational included children aged three m...

BACKGROUND AND PURPOSE Previous studies have shown the hippocampus and basal ganglia to be highly sensitive to hypoxic-ischemic insult. The authors' aim was to evaluate the long-term effects of perinatal asphyxia (PA) on the hippocampus and caudate nucleus in a group of participants born at term and who met the criteria for hypoxic-ischemic encephalopathy (HIE). Additionally, the authors looked...

Executive Summary In the first edition of this report, the Task Force on Neonatal Encephalopathy and Cerebral Palsy outlined criteria deemed essential to establish a causal link between intrapartum hypoxic events and cerebral palsy. It is now known that there are multiple potential causal pathways that lead to cerebral palsy in term infants (see Fig. 1), and the signs and symptoms of neonatal e...

Hypoxic-ischemic neonatal encephalopathy and ensuing brain damage is still an important problem in modern perinatal medicine. In this paper, we would like to share some of the results of our recent studies on neuroprotective therapies in animal experiments, as well as some literature reviews. From the basic animal studies, we have now obtained some possible candidates for therapeutic measures a...