objective: to describe the epidemiological and clinical characteristics of fall injuries in east azerbaijan, iran. methods: this cross-sectional study was based on hospital information system (his) data for patients referred to the imam reza hospital between 2008 and 2013. we recorded the demographic characteristics and epidemiological patterns of patients who were admitted to our center due to...

Accumulating evidence has provided a causative role of zinc (Zn(2+)) in neuronal death following ischemic brain injury. Using a hypoxia model of primary cultured cortical neurons with hypoxia-inducing chemicals, cobalt chloride (1 mM CoCl2), deferoxamine (3 mM DFX), and sodium azide (2 mM NaN3), we evaluated whether Zn(2+) is involved in hypoxic neuronal death. The hypoxic chemicals rapidly eli...

naturally the brain is ineffective in regenerating functional tissue after disease or injury, so to overcome these defects innovative curative strategies such as stem cell transplantation and tissue engineering have to be considered. researchers investigate the use of strategies to attain better functional repair results. one of the important challenges of effective transplantation is the deliv...

abstract objective: to determine the effects of glycemic level on outcome patients with traumatic brain injury . m e t h od s :   from september 2010 to december 2012, all medical records of adult patients with tbi admitted to the emergency room of laura daniela clinic in valledupar city, colombia, south america were enrolled. both genders between 18 and 85 years who referred during the first 4...

The case of Archie Battersbee, a 12-year-old boy who suffered catastrophic hypoxic brain injury, was the subject several Family Division and Appeal Court hearings between April August 2022. During protracted legal process, appeals were made by family to Supreme Court, European Human Rights, United Nations’ Committee on Rights Persons with Disabilities (CRPD Committee). These unsuccessful in ach...

The ischemia-reperfusion-induced damage in human brain microvascular endothelial cells (BMECs) is associated with disruption of the blood–brain barrier. CXC chemokine ligand 5 (CXCL5) reported to be up-regulated ischemic stroke. However, detailed function CXCL5 this pathological process remains largely unclear. To further analyze stroke, an oxygen–glucose deprivation model on BMECs was construc...

Aims Hypoxic-ischemic injury (HI) to the developing brain remains a major cause of morbidity. Hypothermia is currently the only established neuroprotective treatment available for term borns with hypoxic-ischemic encephalopathy, saving one in eight infants from developing severe neurological deficits. Therefore, additional treatments with clinically applicable drugs are indispensable. Furthermo...

Purpose:Hypoxic-ischemic brain injury (HIBI) can cause coma.Several factors may affect the outcome after HIBI and prediction of prognosis is challenging in clinical practice.Magnetic Resonance Imaging (MRI) Electroencephalogram (EEG) are two reliable tools to predict possible damage.We aimed test utility MRI EEG predicting by exploring specific lesion electrophysiological patterns. 
 Metho...

when intracranial pressure (icp) was uncontrollable among patients with severe traumatic brain injuries (stbi) and especially if it raises above 40 mmhg 100% morality was reported. eighty four percent of head injured patients would die if their initial icp is greater than 25 mm hg. decreasing icp through decompressive craniectomy (dc) theoretically may revert increased icp to normal and decreas...

traumatic brain injury (tbi) is one of the most common neurological diseases with no definite treatment. erythropoietin (epo) and progesterone (prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. this study was designed to determine the effect of epo, prog and combination of epo/prog on neurological outcome after traumatic brain injury. ...