Hypothetical proteins are functionally uncharacterized proteins with assigned function using sequence annotation tools. Almost half of the coding regions of several genomes are hypothetical proteins. Therefore, it is of our interest to characterize a hypothetical protein YVRE from the model system Bacillus subtilis using known data. YVRE is assigned the function as a glucono-lactonase using pre...

Anaplasma phagocytophilum is an obligate intracellular bacterium that invades neutrophils to cause the emerging infectious disease human granulocytic anaplasmosis. A. phagocytophilum undergoes a biphasic developmental cycle, transitioning between an infectious dense-cored cell (DC) and a noninfectious reticulate cell (RC). To gain insights into the organism's biology and pathogenesis during hum...

Knowledge of rice genome brings new dimensions to the management of abiotic stresses; however, gene sequences in the rice genome are yet to be assigned structure and function. Hydrogen peroxide, salicylates and jasmonates act as signal molecules in plants employing common machinery to manage abiotic stress. The present work is primarily focused to assign a structurefunction relationship by mode...

An analysis of published data and the results our own studies reveal that activation a peripheral δ2-opioid receptor (δ2-OR) increases cardiac tolerance to reperfusion. It has been found this δ2-OR is localized in cardiomyocytes. Endogenous opioids are not involved regulation resistance The infarct-limiting effect agonist deltorphin II depends on several protein kinases, including PKCδ, ERK1/2,...

We present an extension of Horn-clause logic which can hypothetically add and delete tuples from a database. Such logics have been discussed in the literature , but their complexities and expressibilities have remained an open question. This paper examines two such logics in the function-free, predicate case. It is shown, in particular, that augmenting Horn-clause logic with hypothetical additi...

In antiquity we encounter a distinction of two types of hypothetical syllogisms. One type are the 'mixed hypothetical syllogisms'. The other type is the one to which the present paper is devoted. These arguments went by the name of 'wholly hypothetical syllogisms'. They were thought to make up a self-contained system of valid arguments. Their paradigm case consists of two conditionals as premis...