The aim of our computational modeling is twofold. First, we seek to understand the relative contribution of cell proliferation, fate transition and respecification in mediating the pCLV3:HEC1-GR phenotype. We use the model to check which hypothetical scenarios are compatible with our experimental observations. Second, we aim to get insights into the hec1,2,3 phenotype which admits only limited ...

Definition of the counterfactual Dj . This all takes place at the level of hypothetical manipulations. The space may have a probability measure or just a measure. For some J (Z) = j, define Aj (z) = {z | J (z) = j}. For each element in the set, we “project” μD (z) onto the set. If we embed the set in L , this is clear. Otherwise, there may be other constructions (e.g., embed in space L and for ...

We previously introduced two new protein databases (trEST and trGEN) of hypothetical protein sequences predicted from EST and HTG sequences, respectively. Here, we present the updates made on these two databases plus a new database (trome), which uses alignments of EST data to HTG or full genomes to generate virtual transcripts and coding sequences. This new database is of higher quality and si...

This paper presents a novel algorithm for identification and functional characterization of "key" genome features responsible for a particular biochemical process of interest. The central idea is that individual genome features are identified as "key" features if the discrimination accuracy between two classes of genomes with respect to a given biochemical process is sufficiently affected by th...

Deer hunter surveys commonly employ hypothetical chronic wasting disease (CWD) prevalence scenarios to measure behavioral intentions. These may suffer from bias (i.e. respondents describe unrealistic behaviors in situations) and it is unclear how affects results. We used an online-based survey of Arkansas deer hunters (1) investigate intentions change as CWD hypothetically varies, (2) explore t...

Much of the research on human delay and probability discounting involves the use of hypothetical outcomes, in which participants indicate preferences for outcomes but do not receive them. Research generally shows that hypothetical and potentially real outcomes are discounted at similar rates. One study, however, shows that potentially real cigarettes are discounted more steeply than hypothetica...