Diffusion weighted imaging (DWI) and the trace of diffusion tensor [Trace (D)], a marker of water molecule diffusivity, provide information on structural integrity of nervous tissues. To investigate structural lesions within the brain's neuronal architecture in early stages of Parkinson's disease, 12 patients with disease duration of 3.5 +/- 1.5 years were studied with DWI. Data were compared w...

Abstract Background We performed a search in the PubMed databases, Web of Science, LILACS, MEDLINE, SciELO, and Cochrane Library using keywords COVID-19, Novel coronavirus, corona, 2019-nCoV, SARS-CoV-2, ENT, nose, anosmia, hyposmia, smell, olfactory, ORL, different ENT related symptoms. reviewed published peer-reviewed studies that reported manifestations COVID-19 laboratory-confirmed positive...

Obesity is currently a major global public health problem. As result, in recent decades there has been growing interest studying the impact of this disease on functioning central nervous system. One least understood aspects that obesity sensory systems.The olfactory and gustatory systems are closely related to various vital functions, such as nocifensors activation, stimulation digestive reflex...

Background: There is a lack of evidence-based, prospective studies in treatment of nasal polyposis. The correlations between symptoms, polyp scores and computed tomography (CT) scans have not been studied sufficiently. Little, if any, sense of smell is common in nasal inflammatory disease. It is clinically well-known that the quality of life deteriorates when one starts to lose the sense of sme...

After a total laryngectomy the upper and lower airways are disconnected resulting in a wide range of adverse effects, e.g. deterioration of nasal functions in breathing, loss or decrease of normal sense of smell and taste, as well as loss of normal voice. Recently, a new method that can restore the sense of smell in laryngectomized patients has been developed, the Nasal Airflow-Inducing Maneuve...

BACKGROUND Classical and data-driven classifications of Parkinson's disease (PD) are based primarily on motor symptoms, with little attention being paid to the clustering of nonmotor manifestations. METHODS Clinical data on demographic, motor and nonmotor features, including the Korean version of the sniffin' stick (KVSS) test results, and responses to the screening questionnaire of the nonmo...

The growing healthy aging population in Europe is a heterogeneous group with varying nutritional needs, especially in association with problems like decreased sense of smell and taste, saliva production, chewing and swallowing problems besides all disease problems that put specific demands on the dietary intake and the role of the intestinal metabolism. To investigate this, one must clarify whi...

BACKGROUND TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity. METHODS Olfactory function and nociception was compared between carriers (n = 38) and n...

The association of Parkinson's disease (PD) with an impaired sense of smell was first reported about thirty years ago. Since then, it has become quite firmly established that olfactory dysfunction is one of the first and most prevalent clinical manifestations of this disorder. Recent data from an ongoing prospective study indicate that otherwise unexplained hyposmia in first degree relatives of...