نتایج جستجو برای: hyponatremia rhabdomyolysis
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Rhabdomyolysis is a clinical and biochemical syndrome resulting from skeletal muscle injury and the release muscular cell constituents into extracellular fluid and the circulation (1). Rhabdomyolysis occurs due to drugs, toxins, ischemia and infections. Drug induced rhabdomyolysis mostly occurs with statins but rarely with fibrates. Fibrates are widely used for the treatment of hypertriglycerid...
Rhabdomyolysis may be secondary to trauma, excessive muscle activity, hereditary muscle enzyme defects and other medical causes. Primary hyperaldosteronism is characterised by hypertension, hypokalemia, suppressed plasma renin activity, and increased aldosterone excretion. Rhabdomyolysis is not common in primary hyperaldosteronism. We report here a 42-year-old woman presenting with rhabdomyolys...
INTRODUCTION Cardiovascular benefits and improved survival have resulted in statins becoming the most prescribed drugs in USA. There is a small but significant risk of developing statin induced rhabdomyolysis especially in combination with other lipid lowering medications for example fibrates like Gemfibrozil. CASE PRESENTATION We describe a case of an 82 year old male patient who developed r...
Objective: Unusual or unexpected effect of treatment Background: Rhabdomyolysis is a syndrome characterized by skeletal muscle breakdown, that involves the release of intracellular contents into the circulation, including creatine kinase (CK), myoglobin, electrolytes, organic acids, and purines. Causes of rhabdomyolysis include trauma, exertion, drugs, and toxins (including alcohol), and electr...
OBJECTIVES Terlipressin is safely used for acute variceal bleeding. However, side effects, such as hyponatremia, although very rare, can occur. We investigated the development of hyponatremia in cirrhotic patients who had acute variceal bleeding treated with terlipressin and the identification of the risk factors associated with the development of hyponatremia. DESIGN AND METHODS This retrosp...
BACKGROUND Hyponatremia is the most commonly encountered electrolyte disorder in children. In our country the epidemiology of hospital acquired hyponatremia has hardly ever been explored whereas the administration of hypotonic IV fluids is widely practiced here. Therefore we pioneered to conduct this study to determine the frequency of hospital acquired hyponatremia. METHODS This was a cross ...
Hyponatremia (clinically defined as serum sodium levels of <135 meq/L) is considered to be the most common electrolyte abnormality seen in general hospital patients [1]. Hyponatremia is noted as a side effect associated with various psychotropic medications, especially the antidepressants. The risk of hyponatremia varies from one antidepressant to other. Evidence suggests that compared to other...
OBJECTIVES To determine the risk factors for hyponatremia in patients with epilepsy treated with oxcarbazepine (OXC). METHODS Seventy-three adult patients with epilepsy aged older than 17 years who received OXC therapy were enrolled in this study. Patients who had hyponatremia due to any etiology before OXC therapy and patients receiving OXC therapy for nonepileptic disorders were excluded fr...
Rhabdomyolysis is a clinical and laboratory syndrome that is caused by various etiologies, involving the skeletal muscle. Clarithromycin, like other macrolides, is an inhibitor of CYP450 3A4, the major enzyme responsible for the metabolism of several drugs, in particular some statins. Rhabdomyolysis related to macrolide-statin interaction has previously been described. To date, rhabdomyolysis i...
Hyponatremia defined as a plasma sodium concentration of less than 135 mmol/L is a very common disorder, occurring in hospitalized patients. Hyponatremia often results from an increase in circulating arginine vasopressin (AVP) levels and/or increased renal sensitivity to AVP, combined with an increased intake of free water. Hyponatremia is subdivided into three groups, depending on clinical his...
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