Insulin autoimmune syndrome or Hirata’s disease is an extremely rare condition leading to hypoglycaemia of variable severity due autoantibodies against insulin. We present the first case documented in Czech Republic.

OBJECTIVE To examine whether transfer from animal insulin to human insulin is associated with an increased risk of severe hypoglycaemia. DESIGN Matched case-control study of insulin treated diabetic patients admitted to hospital because of hypoglycaemia during 1984-7, the period when human insulin was introduced into treatment. SETTING Case admissions and control admissions were obtained fr...

Hypoglycaemia is one of the most serious adverse effects diabetes treatment. Older adults are at highest risk to develop hypoglycaemia. Several studies have established important positive role educational interventions on achieving glycaemic control and other clinical outcomes, however, there still a lack in that evaluate impact such type hypoglycaemia elderly patients with 2 diabetes. The purp...

Effects of hypoglycaemia on distinct cognitive processes were assessed with event-related brain-potential (ERP) measures and reaction times in a hybrid selective-attention/response-choice task. One group of subjects received a euglycaemia-hypoglycaemia-euglycaemia treatment order and a second group a euglycaemia-placebo(euglycaemia)-euglycaemia sequence of treatments. During hypoglycaemia, ERP ...

High basal gastrin levels in pure autonomic failure could result from peripheral vagus nerve involvement, whereas the increased response during hypoglycaemia may reflect adrenergic supersensitivity. A reduced gastrin increment in multiple system atrophy was found following insulin-hypoglycaemia and is consistent with decreased gastrin release secondary to diminished central sympathetic nervous ...

HYPOGLYCAEMIA in children may cause listlessness, inattention, pallor, stupor, convulsions and coma, which may be accompanied by tachycardia and sweating. Such non-specific symptoms as cyanotic attacks, reluctance to feed, irritability, convulsions, jittery limb movements and depression of the Moro reflex may occur in the hypoglycaemic newborn infant. A major part of these clinical patterns ari...