The immunocytochemical localization of gamma-glutamyltransferase [(5-glutamyl)-peptide:amino-acid 5-glutamyltransferase, EC 2.3.2.2; gamma-GluTase] was demonstrated in hyperplastic liver induced by the carcinogen 2-acetylaminofluorene (2-AAF). The method used a specific antiserum and protein A-horseradish peroxidase and permitted visualization of antigenic sites at both the light and electron m...

Caries results in the demineralization and destruction of enamel dentine, as disease progresses, irreversible pulpitis can occur. Vital pulp therapy (VPT) is directed towards preservation prevention progression inflammation. The outcomes VPT are not always predictable, there often a poor correlation between clinical signs symptoms, events occurring at molecular level. inflamed expresses increas...

ABSTRACT
 Objective: 
 To determine the frequency of pain in teeth with irreversible pulpitis after single visit root canal treatment using intra-canal cryotherapy.
 Study design: Quasi experimental
 Place and duration study: Department Operative Dentistry, Armed forces institute Dentistry Rawalpindi from 1st June 2017 to 31st December 2017.
 Material Methods: Total 140...

BACKGROUND/AIMS In vivo autofluorescence endoscopic imaging and spectroscopy have been used to detect and differentiate benign (hyperplastic) and preneoplastic (adenomatous) colonic lesions. This fluorescence is composed of contributions from the epithelium, lamina propria, and submucosa. Because epithelial autofluorescence in normal and diseased tissues is poorly understood, this was the focus...

BACKGROUND Gastric cancer is one of the most frequent malignancies in the world, ranking fifth in the Netherlands as a cause of cancer death. Surgery is the only curative treatment for advanced cases, but results of gastrectomy largely depend on the stage of the disease. A better understanding of the mechanisms of progression from a preneoplastic condition through intraepithelial neoplasia to i...

objectives: pain is an unpleasant outcome of endodontic treatment that can be unbearable to patients. instrumentation techniques may affect the frequency and intensity of post-endodontic pain. this study aimed to compare single visit post endodontic pain using mtwo (niti) rotary and hand k-file instruments. materials and methods: in this randomized controlled trial, 60 teeth with symptomatic ir...

Langerhans cells (LC) are skin-resident antigen-presenting that regulate immune responses to epithelial commensal and pathogenic microorganisms. Infection of skin by human papillomavirus (HPV) is commonly persistant can promote malignant transformation. As LCs considered important in control HPV infection, we compared the transcriptome from transformed oncogenic E7 protein HPV16 healthy skin. W...

vital pulp therapy (vpt) is the preferred conservative treatment for preservation of symptomatic pulps in immature permanent teeth. the present case report summarizes vpt of an immature permanent molar with irreversible pulpitis associated with apical periodontitis in a 9-year-old boy. cervical pulpotomy was performed and radicular pulp stump were covered with calcium-enriched mixture (cem) cem...