OBJECTIVE The empirical dietary index for hyperinsulinemia (EDIH) and inflammatory pattern (EDIP) scores assess the insulinemic potentials of habitual patterns, irrespective macronutrient content, are based on plasma insulin response or biomarkers, respectively. glycemic (GI) load (GL) postprandial potential carbohydrate content. We tested hypothesis that patterns promoting hyperinsulinemia, ch...

Either endogenous or exogenous hyperinsulinemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras protein. Increased availability of farnesylated Ras at the plasma membrane enhances mitogenic responsiveness of cells to various growth factors, thus contributing to progression of cancer and atherosclerosi...

The contribution of obesity to cardiovascular risk has not been adequately appreciated because of a failure to recognize the involvement of upper-body predominance of body weight with hypertension, diabetes, and hypertriglyceridemia even in the absence of significant overall obesity. This article examines the evidence that upper-body obesity, as usually induced by caloric excess in the presence...