Vol.31, No. 4, 1985 649 tecting hypercholesterolemia must have the best possible analytical performance. We suggest that, in screening a population for hypercholesterolemia, serum or plasma samples are preferable to blood spots on fiter paper. Instruments such as the Cobas-Bio centrifugal analyzer require less than 50 L of sample and the typical overall CV is 4% for assays of cholesterol in pla...