objectives: it is important to recognize any risk factors for the development of injuries in the athletic population. the aim of this study was to investigate the association between joint hyper mobility and low back pain in iranian hyper mobile and non-hyper mobile athletes. methods: 50 athletic patients with low back pain (age=23.20±12.79 years) and 51 healthy athletes (age=24.28±13.70) from ...

Abstract Dysregulated expansion and/or activation of mast cells have detrimental consequences in allergic disease. In humans, homozygous or compound heterozygous deletions DOCK8 cause a combined immunodeficiency characterized by disorders. Based on this evidence, we hypothesized that may be negative regulator cell function. To address hypothesis, used mice with loss-of-function mutation Dock8 (...

BACKGROUND Job's syndrome (hyper IgE syndrome) is a very rare primary immunodeficiency disease that has an annual approximate incidence of less than 1/1,000,000. This manuscript aims to provide education regarding diagnosis and management strategies of this syndrome worldwide. CASE REPORT A 6-year-old boy was seen at the clinic secondary to persistent pruritus interfering with sleep. At the a...

Studying rare inherited immune disorders in patients has led to improved understanding of how the human immune system is fundamentally regulated. This knowledge is needed to develop new therapeutic agents for immunodeficiency, autoimmunity, cancer, and transplantation. One such illustrative disorder is DOCK8 deficiency, whose molecular etiology was discovered only in the past year. The discover...