Purpose: To utilize hydroxybutyl-β-cyclodextrin (HB-β-CD) and polyvinyl pyrrolidone (PVP) for the enhancement of the transdermal delivery of glimepiride (GMD). Methods: Matrix-type transdermal patches containing GMD, drug coprecipitate or its inclusion complex were prepared using different gelling agents, viz, hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), carbopol and chi...

Purpose: To develop an oral capsule-based chronomodulated drug delivery system of salbutamol sulphate for the treatment of nocturnal asthma. Methods: The basic design of the proposed dosage form entails an insoluble cross-linked capsule body filled with drug-loaded pellets sealed with hydrocolloid plug and a soluble capsule cap. Various hydrocolloid polymers, namely, hydroxypropyl methylcellulo...

In this study, cationic cellulose (CC) was prepared by etherifying commercial with (3-chloro-2 hydroxypropyl) trimethylammonium chloride (CHPTAC) in an alkaline medium. The CC characterized using Fourier transform infrared spectrometry (FTIR), scanning electron microscopy (SEM), differential calorimetry (DSC), and nuclear magnetic resonance (NMR). characterization results affirmed the successfu...

Pore geometry characterization-methods are important tools for understanding how pore structure influences properties such as transport through a porous material. Bottlenecks can have large influence on and related properties. However, existing methods only catch certain types of bottleneck effects caused by variations in size. We here introduce new measure, geodesic channel strength, which cap...

The leavening of gluten-free rice flour bread is enhanced when soymilk used instead water. However, as the amount batter increased to bake in shape a square, crumb becomes less dense. This study aimed investigate effects hydrocolloids (xanthan, guar, curdlan, methylcellulose, and hydroxypropyl methylcellulose) on hollowing. When 0.5 % methylcellulose or was added made with soymilk, could be bak...

The sustained release tablets were formulated by using the combination of various retardant polymers/excipient. polymers used hydroxypropyl methylcellulose, Micro Crystalline Cellulose and Sodium starch glycolate. present investigation involves formulation evaluation Valsartan with a view to prolong drug in gastrointestinal tract consequently into plasma. It showed good linearity reproducibilit...