The use of hydroxyethyl starch (HES) in sepsis has been shown to increase mortality and acute kidney injury. However, the knowledge of the exact mechanism by which several fluids, especially starch preparations may impair end-organ function particularly in the kidney, is still missing. The aim of this study was to measure the influence of different crystalloid and colloid fluid compositions on ...

The present study was designed to determine the effects of hemodilution with gelatine (GEL) and hydroxyethyl starch (HES) on hematocrit, blood viscosity, systemic hemodynamics, and central retinal arterial blood flow in anaesthetized pigs. 20 pigs were studied. Hypervolemic hemodilution was induced by 30 ml kg-1h-1 GEL (n=10) or HES (n=10) infused over 30 min. The hematocrit decreased comparabl...

Meybohm and colleagues hypothesise that so-called ‘correct’ administration of hydroxyethyl starch (HES) may be beneficial and may provide new guidelines for clinical use of HES, but this is not supported by trial data [1]. In contrast, subgrouping trials according to ‘presumable correct indication’ does not change the mortality estimate (see Figure 1). There is also very little statistical hete...

Preparation of microcapsules through interfacial cross-linking of soluble starch/hydroxyethyl starch and bovine serum albumin (BSA) with terephthaloyl chloride is described. The proteinase inhibitor aprotinin, either native or active site protected, was microencapsulated, being incorporated in the aqueous phase. The influence of aqueous phase pH, BSA, and terephthaloyl chloride concentrations a...