The dose-frequency requirement for carbamazepine (CBZ) in children was investigated using serial saliva samples to determine the daily fluctuation in drug levels. Mixed saliva was collected from 6 children (aged between 6 and 13 years) in a steady state, on each of two different dose-frequency resulted in smaller fluctuations in saliva concentration and a shorter time with levels outside the th...

Human milk and saliva from newborn infants were analyzed for their content of lactoperoxidase and thiocyanate. The activity of lactoperoxidase in infant saliva was variable but generally higher than that found in calf saliva. In contrast, the activity in human colostrum was low ( approximately 5%) compared with that found in cow's milk. The enzyme was resistant to gastric juice. Thiocyanate was...

Little is known about the involvement of saliva in gingival overgrowth (GO). It was hypothesized that, in this situation, the composition of saliva is altered. Thus, proteins, albumin, cytokines, and growth factors in whole and glandular saliva were investigated. Differences between glandular and gingival contributions to the composition of saliva were explored in patients medicated with cyclos...

The case of a 4.5-year-old girl with autosomal recessive vitamin D dependency is described. Although she had been effectively treated since one month postpartum with 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3, alfacalcidol], her mean alkaline phosphatase (EC 3.1.3.1) activity in serum increased to 3680 U/L from a stable value [335 (SD 50) U/L; n = 12] within three weeks, then returned to bas...

although salivary alkaline phosphatase (alp) can balance de- and remineralization processes of enamel, there is no evidence regarding its effects on the concentrations of calcium and phosphate in saliva. the present study aims to determine the relationship between salivary alp activity and the concentrations of calcium and phosphate in saliva. in this cross-sectional study, we evaluated salivar...

background: immunochromatographic based rk39 antibody detection test became popular for the diagnosis of vis­ceral leishmaiasis (vl) because of high sensitivity, rapidity, easy to interpret, and cost effectiveness. however, false positive result after complete cure of the patients is the major limitation with this test. the aim of the study to access the usefulness of non-invasive samples i.e. ...

A pilot study was carried out on the detection of trypanosome-specific antibodies in saliva for diagnosis of sleeping sickness. All twenty-three saliva samples of parasitologically confirmed Trypanosoma brucei gambiense patients tested positive in an indirect enzyme-linked immunosorbent assay, whereas all 14 saliva samples of a negative control group remained negative. Trypanosome-specific anti...

Saliva and polymorphonuclear leukocytes (PMNs) are both important players in the innate defense of the oral cavity, but little is known of the effect of saliva on PMN function. In this study, we investigated the effect of saliva on the adhesion of Fu-sobacterium nucleatum and Candida albicans to human granulocytic-differentiated HL-60 cells. The adhesion of FITC-labeled F. nucleatum and C. albi...