During the early stages of COVID-19 pandemic, many cities throughout world observed a marked increase in sudden cardiac death (SCD). The p.S1103Y-SCN5A common variant, present ∼8-10% individuals African descent, may be circumstance-dependent, SCD-predisposing, pro-arrhythmic polymorphism setting hypoxia-induced acidosis or QT-prolonging drug use. In light FDA’s Emergency Use Authorization hydro...

Background Hydroxychloroquine (HCQ) is currently recommended for all pregnant women with systemic lupus erythematosus (SLE) if tolerated. Some studies have reported an increased risk of malformations associated HCQ, but others find no risk. Objectives To assess the major congenital (MCM) exposure to HCQ during 1st trimester in offspring SLE. Methods We conducted a population-based cohort study ...

Background: The COVID-19 pandemic led to a violent debate about the efficacy of repurposed drug hydroxychloroquine (HCQ) and new broad-spectrum antiviral (remdesivir) randomized controlled trials (RCTs) observational studies. To understand conflicting results in literature, we performed meta-synthesis determine whether intrinsic qualitative criteria within studies may predict apparent or ineffe...

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PEAG Adverse drug reaction Hydroxychloroquine P. Saiag, Service de Dermatologie, CHU Ambroise Paré, 9, avenue du Général de Gaulle, F-92104 Boulogne Cedex (France) Antimalarial drugs may induce numerous cutaneous adverse drug reactions (ADR): pruritus, lichenoid and urticarial skin eruptions, mucocutaneous hyperpigmentation, as well as exacerbation of psori-sis. We report here a case of hydroxy...

Background: The intrinsic autophagy-dependence of human tumor cell lines has been demonstrated using CRISPR screens showing that some respond in similar ways to loss core autophagy genes as they do an established essential gene such proliferating nuclear antigen (PCNA). Pharmacologic inhibition can be achieved lysosomotropic agents hydroxychloroquine (HCQ) interfere with fusion the autophagosom...

Background Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disorder characterized by lymphocytic infiltration and functional impairment of exocrine glands, resulting in dryness the eyes, mouth extra-glandular manifestations numerous organs. Immunopathology pSS associated with prominent B cell hyperactivity reflected elevated serum IgG levels, autoantibody production, immune complex for...

First-line treatment for cutaneous lupus erythematosus involves the use of antimalarials. Treatment response is highly variable with some patients responding well to hydroxychloroquine (HCQ), necessitating addition quinacrine (QC) and others refractory from both (NR). Here we used unsupervised learning highlight differences between immune infiltrate composition three groups. Infiltrate was char...

The absence of designated remedies for coronavirus disease 19 (Covid-19) and the lack treatment protocols drove scientists to propose new small molecules attempt repurpose existing drugs against various targets severe acute respiratory syndrome 2 (SARS-CoV-2) in order bring forward efficient solutions. main protease (Mpro) is one most promising drug due its crucial role fighting viral replicati...

Sustained autophagy contributes to the metabolic adaptation of cancer cells to hypoxic and acidic microenvironments. Since cells in such environments are resistant to conventional cytotoxic drugs, inhibition of autophagy represents a promising therapeutic strategy in clinical oncology. We previously reported that the efficacy of hydroxychloroquine (HCQ), an autophagy inhibitor under clinical in...