introduction during the process photodynamic therapy (pdt), bleaching of photosensitizer induced by irradiation and generation of reactive oxygen species (ros) can provide some information concerning the efficiency of treatment. since gold nanoparticles (gnps) have been highlighted as efficient drug delivery systems, in this study, by utilizing gnps conjugated with 5 aminolevulinic acid (5-ala-...

BACKGROUND Gold nanoparticles (GNPs) are likely to provide an attractive platform for combining a variety of biophysicochemical properties into a unified nanodevice with great therapeutic potential. In this study we investigated the capabilities of three different natural polyphenols, epigallocatechin-3-gallate (EGCG), resveratrol (RSV), and fisetin (FS), to allow synergistic chemical reduction...

The study of cellular processes such as organelle transport often demands particle tracking with microsecond time-resolution and nanometer spatial precision, posing significant challenges to existing tracking methods. Here, we have developed a novel strategy for two-dimensional tracking of gold nanoparticles (GNPs) with 25 mus time resolution and approximately 1.5 nm spatial precision, by using...

UNLABELLED BACKGROUND Nanoparticles are potentially used for early cancer detection, accurate diagnosis, and cancer treatment. RESULTS In this paper, the breast cancer cells treated with gold colloidal suspension were carefully studied by surface-enhanced Raman scattering (SERS) spectra. Raman spectroscopy combining with high-resolution electron microscope is employed to investigate the in...

In the recent years, application of nanoparticles in diagnosis and treatment of cancer has been the issue of extensive research. Among these studies some have focused on the dose enhancement effect of gold nanoparticles (GNPs) in radiation therapy of cancer. On the other hand, some studies indicated energy dependency of dose enhancement effect, and the others have studied the GNP size effect in...

The synthesis and biomedical application of noble metal nanoparticles specially gold nanoparticles (GNPs) is a promising field of research and has garnered the attention of vast groups of researchers. Bulk metallic gold (Au) is known to be chemically inert. However, when the size of gold is reduced to nanometer ranges it starts to show diverse biological properties [1]. GNPs find application in...

We present a new method of rapid sequence-selective microRNA (miRNA) detection with small amount of sample using power-free PDMS microfluidic device and gold-nanoparticles (GNPs). Target miRNA hybridized to probe DNA was labeled by DNA-coated GNPs, which also act as signal amplifiers. This method allows us to detect miRNA of certain sequence in 30 min with 0.5 μL sample volume. This method migh...

Background: Normoxic type MAGICA gel dosimeters are established for dose quantification in three dimensions for radiotherapy. Objective(s): The ability of MAGICA polymer gel was assessed by experimental measurements method for studying the effect of gold nanoparticles (GNPs) in dose enhancement under the external 18MV radiotherapy practices. <...

Since the existence of nanoparticles in our environment has already attracted considerable attention due to their possible toxic impact on biological systems, the field detection of nanoparticles is becoming a technology that will be much in need. We have constructed a piezoelectric sensor with an antibody-coated electrode. The antiserum can bind gold nanoparticles with a high degree of selecti...

A simple and accurate label-free amperometric immunosensor for α-fetoprotein (AFP) detection is developed based on gold nanorods (GNRs) with different aspect ratio and compared with gold particles (GNPs). The positively charged GNRs and GNPs due to the surface immobilized cetyltrimethyl ammonium bromide (CTAB) can adsorb the negatively charged AFP antibody (Ab) directly. The presence of the GNR...