the search for new stationary phases has been one of the predominant concerns in high performance liquid chromatography (hplc) in order to achieve better resolutions, longer column lives, and reduce the time of analysis. a chromatographic packing for separation of underivatized amino acids (aas) were prepared by dynamically coating 2-amino tetraphenyl prophyrin (atpp) on a c-18 reversed-phase p...

The formation of deposits by evaporation droplets contaminated Bacillus spores was investigated, focusing on the role spore and material properties. Droplets containing hydrophilic to hydrophobic were deposited materials (stainless steels, polypropylene, glass). presence within droplets, as well hydrophobicity plays a major in kinetics droplet shape during drying while pattern dried deposit aff...

The main objective of this research is theoretical and experimental investigation of the surfaces modification of SU8, PDMS, SiO2 and Si by RF plasma treatment. Physical-chemical reactions at room temperature can be used for the modifications of the surfaces in plasma, by modifying the contact angle, superficial polymerization, or by creating hydrophilic and/or hydrophobic regions on the surfac...

We created a homology model of the homo-tetrameric pore domain of HERG using the crystal structure of the bacterial potassium channel, KvAP, as a template. We docked a set of known blockers with well-characterized effects on channel function into the lumen of the pore between the selectivity filter and extracellular entrance using a novel docking and refinement procedure incorporating Glide and...

It has been shown that the flow of a simple liquid over a solid surface can violate the so-called no-slip boundary condition. We investigate the flow of polar liquids, water and glycerol, on a hydrophilic Pyrex surface and a hydrophobic surface made of a Self-Assembled Monolayer of OTS (octadecyltrichlorosilane) on Pyrex. We use a Dynamic Surface Force Apparatus (DSFA) which allows one to study...

A discussion is presented of contributions of the Zaccai group to the understanding of flexibility in biological macromolecules using dynamic neutron scattering. The concept of resilience as introduced by Zaccai is discussed and investigated using molecular dynamics simulation on camphor-bound cytochrome P450. The resilience of hydrophilic residues is found to be more strongly affected by hydra...

Biliary proteins are speculated to play an important role in modulating nucleation of cholesterol crystals from supersaturated gallbladder bile, acting either as pro- or antinucleating agents. However, conflicting results have been obtained in attempts to isolate specifically active proteins. Our hypothesis, therefore, was that this may be a nonspecific effect of proteins, related to their seco...