Congenital heart defects (CHDs) represent the most common form of human birth defects; approximately one-third of heart defects involve malformations of the outflow tract (OFT). Maternal diabetes increases the risk of CHD by 3-5 fold. During heart organogenesis, little is known about the effects of hyperglycemia on hemodynamics, which are critical to normal heart development. Heart development ...

Web Services Standards haben sich im Laufe der vergangenen Jahre stark weiterentwickelt, unter anderem aber auch viel „Hype“, d.h. überzogene Erwartungen, verursacht. Zwar gibt es für Web Services Technologie breite Unterstützung in der Softwareindustrie und der Nutzen bei der Integration heterogener Softwarelandschaften ist unbestritten. Allerdings ergeben sich insbesondere beim Einsatz in unt...

Rationale: The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cells make important contributions to OFT formation and aortic arch remodeling. Although numerous signaling pathways, including Notch, have been implicated in this process, the rol...

Research on new compounds of therapeutic value for behavioral disorders has progressed recently. Several studies have reported neuropharmacological activities of plant derived terpenes. Farnesol is a sesquiterpene whose most popular source is fruits but the anxiolytic activity for farnesol is still unknown. The present study was conducted on 32 male Swiss Albino mice (8 in each group) to evalua...