A new spectrophotometric method for the estimation of tamsulosin hydrochloride in pharmaceutical dosage forms has been developed and validated. The method is based on reaction between drug and bromophenol blue and complex was measured at 421 nm. The slope, intercept and correlation coefficient was found to be 0.054, -0.020 and 0.999, respectively. Method was validated in terms of specificity, l...

Conversion of 2-oxoadipic acid to lysine with Saccharomyces cerevisiae was accomplished in aerated and agitated fermentors under fermentation conditions resembling those used in baker's yeast process. With this process, a yeast product containing about 16 per cent hot water-extractable lysine (calculated as hydrochloride) was obtained. The conversion efficiency of 2-oxoadipic acid to lysine was...

Benazepril hydrochloride contains two stereogenic centers, but is currently available as single enantiomer (S,S configuration) for the treatment of hypertension. Its enantiomer (R,R configuration) and the diastereoisomeric pair (R,S and S,R) can be regarded as impurities. Stereochemical stability of S,S isomer of benazepril hydrochloride and its potential susceptibility to conversion in the.act...

In this work was synthesized an amino-steroid derivative (4); the route involved preparation of dihydrotestosterone-hemisuccinate (2) by the esterification of dihydrotestosterone (1) using succinic anhydride and pyridine (method A) or using succinic acid and 1,3 dicyclohexylcarbodiimide in presence of p-toluensulfonic acid (method B). After 2 was coupled to 4-hidroxy benzoic acid using 1,3 dicy...

Thyroxine-binding globulin was isolated from human plasma by ammonium sulfate fractionation, chromatographic separations on diethylaminoethyl-Sephadex, gel chromatography, and two different electrophoretic procedures. The highly purified was homogeneous when subjected to polyacrylamide gel electrophoresis, ultracentrifugation analyses, and immunochemical determinations. The weight average molec...

We examined the effects of oral glucosamine hydrochloride (GlcN), N-acetyl-D-glucosamine (GlcNAc) and d-glucose (Glc) administration on plasma total free amino acid (PFAA) concentrations in dogs. The PFAA concentrations increased in the control group and the GlcNAc group at one hour after feeding, and each amino acid concentration increased. On the other hand, in the GlcN group and the Glc grou...