Directional growth of π-basic oligothiophene stacks on solid substrates is achieved by self-organizing, surface-initiated disulfide exchange polymerization. Successful addition of co-axial π-acidic stacks by templated hydrazone exchange provides general access to multicomponent architectures of unique complexity.

We report full details of a method for 1,3-reductive transposition of α-alkoxy-α,β-unsaturated hydrazones to provide E-alkenes with high 1,4-stereocontrol between the two respective allylic stereocenters. The process couples a chelation-controlled reduction of the hydrazone with an in situ allylic strain controlled retro-ene reaction of an allyl diazene, i.e., an allylic diazene rearrangement. ...

New Schiff bases, hydrazones and semicarbazones derived from 1,2-dihydro-4-hydroxy-6-methyl2-oxoquinoline-3-carbaldehyde, have been synthesized. The semicarbazone was subjected to react with 2,3-dichloroquinoxaline, chloroacetic acid, and oxalyl chloride affording multiaza­ heterocycles substituted to quinolone moiety at position 3. Condensation of the 2-imidazolidinethione derivative with some...

Although salicylaldehyde azine (3) was reported in 1985 as the single product of the reaction of ethyl 2-oxo-2H-chromene-3-carboxylate (1) with hydrazine hydrate, we identified another main reaction product, besides 3, which was identified as malono-hydrazide (4). In the last two decades, however, some articles have claimed that this reaction afforded exclusively hydrazide 2 and they have repo...

We expand the possibilities in hydrazone based dynamic combinatorial chemistry with a series of new building blocks incorporating heterocyclic motifs. The synthetic procedure allows efficient access to building blocks with the general structure (MeO)(2)CH-Heterocycle-C(O)NHNH(2), originating from heterocycles with an amine and an ester functionality. The equilibrium distribution of macrocyclic ...

3. The presence of equimolar concentrations of pyridoxal phosphate prevented the inhibition by isoniazid. Stable hydrazones of isoniazid did not inhibit transaminase activity. These compounds, which were stable in the presence of heavy suspensions of B.C.G. organisms, had tuberculostatic activity comparable with isoniazid. 4. Transaminase activity was found in extracts of cells which had been e...

A number of new 5-[(naphthalen-5-yloxy)methyl]-1,3,4-oxadiazole derivatives, 2-5 and 8-11, were synthesized. The 2-{5-[(naphthalen-5-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio}acetohydrazones 6a and 6b were synthesized by the reaction of the hydrazide 4 with the corresponding monosaccharides. Cyclization of the sugar hydrazones 6a and 6b with acetic anhydride afforded the substituted oxadiazoline d...