The turnover of the acid mucopolysaccharides, hyaluronic acid (HA) and chondroitinsulfuric acid (CSA), of skin has been studied in normal rats (1) and in animals treated with the adrenocortical hormones, 17-hydroxycorticosterone and 11-dehydro-17-hydroxycorticosterone (2). It was shown that the administration of these adrenal steroids to otherwise normal rats resulted in a decreased turnover of...

Hyaluronic acid (HA) has currently several therapeutic applications: in ophthalmology, osteoarthritis, wound healing, tissue regeneration, postoperative anti-adhesion and anesthetic medicine. In the last ten years, it has also been successfully investigated in the field of drug delivery, in the form of conjugates or hydrogel depot systems. HAylation, the covalent conjugation of HA to bioactive ...

Hyaluronic acid (HA) microparticles crosslinked with divinyl sulfone (DVS) are primarily used in viscosupplementation to restore the viscoelastic properties of synovial fluid in the treatment of joint diseases. The crosslinking degree provides the swelling and rheological properties required for injectable application and biological stability. In this work, we studied the effects of alkaline me...

OBJECTIVES The matrix protein hyaluronic acid (HA, hyaluronan) has possibly additional immune-regulatory functions in inflammation. We aimed at evaluating serum HA concentrations in critically ill patients. DESIGN AND METHODS We analyzed serum HA levels in 164 critically ill patients at a medical ICU and 61 healthy controls, with respect to organ dysfunction, systemic inflammation and mortali...

INTRODUCTION Hyaluronic acid (HA) is a major constituent of the extracellular matrix. Among its many biological functions, HA plays a critical role in cartilage, where large aggrecan-HA complexes that provide the resistance to compressive load enmesh the collagen network. The carboxyl groups of the HA molecule in physiological conditions become charged and contribute to the osmotic pressure of ...

The potential advantages of hyaluronic acid (HA) production by metabolically-engineered Lactococcus lactis is constrained by the lower molecular weight and yield of HA obtained in these strains, compared to natural producers. Earlier studies have correlated lower HA yield with excessive lactate production in L. lactis cultures (Chauhan et al., 2014). In the present study, a three-fold increase ...

In this study, bi-component alginate-hyaluronic acid (AHA) fibers were developed by using two different routes. the first method, sodium alginate dope solution was extruded into a coagulation bath containing CaCl2 and subsequently dip-coated with hyaluronic (HA) whereas, in second acid-containing directly bath. The resulting AHA then dehydrated 25–100% v/v acetone solutions dried air. character...

Full lips have always been associated with youth and beauty. Because of this, lip enhancement is one of the most frequently requested procedures in a cosmetic practice. For novice injectors, we recommend hyaluronic acid (HA) as the filler of choice. There is no skin test required; it is an easily obtainable, "off-the-shelf" product that is natural feeling when skillfully implanted in the soft t...

The aim of this study was to evaluate the efficacy of a hyaluronic acid containing eye drop in ameliorating ocular surface pathology and discomfort in canine keratoconjunctivitis sicca (KCS). Twenty five dogs with KCS treated with a topical carbomer (CA)-based tear replacement gel were moved to treatment with a hyaluronic acid (HA)-containing tear replacement eye drop. Dogs were subject to a fu...