Background: Glycophorin A (GPA) is one of two glycoproteins found on the surface human red blood cells (RBCs) that constitute MNS group system. The structure GPA’s extracellular domain unknown despite previous attempts using X-ray crystallography and NMR spectroscopy. As a result, there knowledge gap regarding antigen presentation. This hinders production monoclonal antibodies (mAbs) against an...

Histocompatibility antigens on the surface of human lymphoblastoid cells were quantified by a microadsorption technique. During the course of measles virus infection, no quantitative or qualitations in surface HLA antigens were observed. In contrast, infection with poliovirus type 1 or vesicular stomatitis virus, or treatment with puromycin (50 microgram/ml) resulted in a significant decrease i...

Interferon gamma (IFN-gamma) induces expression of class II major histocompatibility complex (MHC)-encoded antigens in immunocompetent cells. To gain further insight into the mechanism of this induction, we prepared somatic cell hybrids between different human cell lines and a murine cell line, RAG, that does not express murine class II MHC antigens before or after treatment with murine IFN-gam...

background there have been studies regarding the prevalence of hepatitis b surface antigen (hbsag) and anti-hepatitis c antibody (hcvab) in iran. however, the majority of these have reported a variety of rates, depending on their study population, which limits the generalizability of their results to the general population. on the other hand, cultural diversity in the different provinces of ira...

conclusions these findings indicated the association of the hbsag titer and serum ifnar2 in hbsag clearance in hepatitis b virus- infected patients. in consequence, immune mechanisms related to ifn-α/β signaling might be responsible in chb outcome. background loss of hepatitis b surface antigen (hbsag) in chronic hepatitis b (chb) infection is a favorable outcome. type i interferon (ifni) has a...

Sera from 30 patients with astrocytoma were tested for antibody reacting with cell surface antigens of cultured autologous astrocytoma cells. Ten percent of the patients had antibody detectable by mixed hemadsorption assays, approximately 50% by immune adherence and protein A assays, and 100% by anti-C3-mixed hemadsorption assays. Absorption analysis of reactive sera with autologous, allogeneic...