Background—We have observed direct (noncatecholamine-blocking) negative inotropic effects of the selective 2adrenoceptor (AR) antagonist ICI 118,551 in myocytes from failing human ventricle. In this study we characterize the effect in parallel in human myocytes and in myocytes from animal models where 2ARs or Gi proteins are overexpressed. Methods and Results—Enzymatically isolated, superfused ...
