Background and Objectives: Alkaline phosphatase activity, mineralized matrix, osteogenic-related gene expression have been shown to increase in response bone morphogenetic protein-9 (BMP-9). In this study, spheroids derived from human gingival stem cells were used determine the effects of BMP-9 on cell survival, osteogenesis, mineralization. Materials Methods: Human produce then grown concentra...

Purpose: To determine the regulation of the expression of osteoprotegerin and receptor activator of nuclear factor-kappa B ligand in human dental follicle cells by colony-stimulating factor-1, parathyroid hormone-related protein and bone morphogenetic protein-2. Materials and Methods: Primary human dental follicle cells were cultured. The fifth passaged human dental follicle cells were separate...

We identified an amino acid change (p.G92E) in the Bone Morphogenetic Protein antagonist NOGGIN in a 22-month-old boy who presented with a unilateral brachydactyly type B phenotype. Brachydactyly type B is a skeletal malformation that has been associated with increased Bone Morphogenetic Protein pathway activation in other patients. Previously, the amino acid change p.G92E in NOGGIN was describ...