Objective: HTLV-1 and HTLV-2 are widespread worldwide and endemic in several areas such as Northeastern Iran. The present survey aimed to determine the prevalence of HTLV-1 and HTLV-2 among healthy individuals in Neyshabour City during the years of 2010-2014. Methods: A total of 8054 blood samples were collected from participants referred to the great medical diagnostic laboratory in Neyshabur,...

Reported at the beginning of the 1980s, Human T lymphotropic viruses type 1 and 2 (HTLV1, HTLV 2) were the first retroviruses to have been detected in human beings. HTLV 1 was isolated from adult T-cell leukemia (ATL) and first described by Takatsuki et al. in Japan in 1976, as a malignancy that only affects T cells and only in adults (1, 2). Albeit infrequent, HTLV-1 infection may lead to seve...

Cytotoxic T lymphocytes (CTLs) play a central role in the protective immune response to human T-lymphotropic virus 1 (HTLV-1). Here we consider two questions. First, what determines the strength of an individual's HTLV-1-specific CTL response? Second, what controls the rate of expression of HTLV-1 in vivo, which is greater in patients with HAM/TSP than in asymptomatic carriers with the same pro...

The present study investigated the frequency of the mutations at positions -550 and -221 of the mannose-binding lectin (MBL) gene in a sample of 75 human T-cell lymphotropic virus (HTLV) infected patients and 96 HTLV seronegative controls, in order to evaluate the occurrence of a possible association between the polymorphism and HTLV infection. A sequence specific primer-polymerase chain reacti...

Human T-lymphotropic virus type 1 (HTLV-1) was the first human oncovirus isolated by Gallo et al. in 1980 and established as an etiological agent for adult T-cell leukemia/ lymphoma (ATL). Although more than 15 million individuals are infected by HTLV-1 through the world, the spread of the virus is highly endemic. The HTLV-1 infection is prevailing in southwestern Japan, inter-tropical Africa, ...

introduction: transfusion-transmitted infections (tti) continue to be a major challenge for blood transfusion organizations in the world and multi- transfused patients (mtps) are at higher risk of infection. htlv-1 is a retrovirus that easily transmitted via blood cell products. the aim of this study is determine the seroprevalence of htlv-1 in major thalassemic patients from kermanshah provinc...

BACKGROUND Periodontal diseases (PDs) are infectious diseases in which periodontopathogens trigger chronic inflammatory and immune responses that lead to tissue destruction. Recently, viruses have been implicated in the pathogenesis of PDs. Individuals infected with human T lymphotropic virus 1 (HTLV-1) present with abnormal oral health and a marked increased prevalence of periodontal disease. ...

Human T-lymphotropic virus type 1 (HTLV-I) is an important global health problem in the world mainly in the endemic areas of HTLV-I infection. It was previously reported that Mashhad, in northeastern Iran, is a new endemic region of HTLV-I. The aim of this study was to examine the prevalence and phylogenetic analysis of HTLV-I in Sabzevar, located in the southeast of Mashhad. In this cross-sect...

In tropical or subtropical areas such as Southern Japan, the Caribbean, Central and South America, both human T-cell lymphotropic virus type I (HTLV-I) and Strongyloides stercoralis infection are endemic (4, 8). Several studies have documented an unexpectedly high prevalence of S. stercoralis in HTLV-I carriers and of HTLV-I among S. stercoralis carriers. The links between two such taxonomicall...

The prevalence of human T-cell lymphotropic virus (HTLV-1/2) infection among puerperae in the State of Mato Grosso, Brazil, is unknown. Through this cross-sectional study, the prevalence of HTLV-1/2 infection among puerperae attended at three public maternity hospitals in Cuiabá, State of Mato Grosso, was defined. Between April and September 2006, 3,831 deliveries took place and 2,965 puerperae...