نتایج جستجو برای: hspb1

تعداد نتایج: 443  

Journal: :Biochimica et biophysica acta 2009
Michel J Vos Bart Kanon Harm H Kampinga

BACKGROUND The HSPB family is one of the more diverse families within the group of HSP families. Some members have chaperone-like activities and/or play a role in cytoskeletal stabilization. Some members also show a dynamic, stress-induced translocation to SC35 splicing speckles. If and how these features are interrelated and if they are shared by all members are yet unknown. METHODS Tissue e...

Journal: :Physiological genomics 2009
Jason W Ross Morgan D Ashworth Daniel R Stein Oliver P Couture Christopher K Tuggle Rodney D Geisert

Early embryonic development in the pig is characterized by a rapid elongation of the conceptus trophectoderm on days 11-12 of gestation. Initially, the conceptus trophoblast is morphologically rearranged from a 10-mm sphere into a tubular shape, transitioning into a thin filamentous form >150 mm in length in 2-3 h, followed by continued expansion within the uterine lumen for several days. Conce...

Journal: :The open inflammation journal 2011
John S Giuliano Patrick M Lahni Hector R Wong Derek S Wheeler

Heat shock proteins (HSPs) are molecular chaperones that facilitate the proper folding and assembly of nascent polypeptides and assist in the refolding and stabilization of damaged polypeptides. Through these largely intracellular functions, the HSPs maintain homeostasis and assure cell survival. However, a growing body of literature suggests that HSPs have important effects in the extracellula...

Journal: :International journal of molecular medicine 2013
Yunjuan Zhang Lawrence Owusu Wei Duan Tao Jiang Shizhu Zang Ayaz Ahmed Yi Xin

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third highest cause of cancer-related mortality in humans. Epigallocatechin-3-gallate (EGCG) has been shown to inhibit the metastatic activity of certain cancer cells. The aim of this study was to determine the effects and molecular mechanism(s) of action of EGCG in human HCC cells. A migration and invasion assay f...

Journal: :Cancer research 2013
Masaki Shiota Jennifer L Bishop Ka Mun Nip Anousheh Zardan Ario Takeuchi Thomas Cordonnier Eliana Beraldi Jenny Bazov Ladan Fazli Kim Chi Martin Gleave Amina Zoubeidi

Defining the mechanisms underlying metastatic progression of prostate cancer may lead to insights into how to decrease morbidity and mortality in this disease. An important determinant of metastasis is epithelial-to-mesenchymal transition (EMT), and the mechanisms that control the process of EMT in cancer cells are still emerging. Here, we report that the molecular chaperone Hsp27 (HSPB1) drive...

2012
Xu Yan Cao Lan-Qin Jin Long-Yu Chen Zhu-Chu Zeng Gu-Qing Tang Can-E Li Guo-Qing Duan Chao-Jun Peng Fang Xiao Zhi-Qiang Li Cui

OBJECTIVE To investigate the differential protein profile of human lung squamous carcinoma (HLSC) and normal bronchial epithelium (NBE) and provide preliminary results for further study to explore the carcinogenic mechanism of HLSC. METHODS Laser capture microdissection (LCM) was used to purify the target cells from 10 pairs of HLSC tissues and their matched NHBE, respectively. A stable-isoto...

Journal: :Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013
Serena Carra Paola Rusmini Valeria Crippa Elisa Giorgetti Alessandra Boncoraglio Riccardo Cristofani Maximillian Naujock Melanie Meister Melania Minoia Harm H Kampinga Angelo Poletti

The family of the mammalian small heat-shock proteins consists of 10 members (sHSPs/HSPBs: HSPB1-HSPB10) that all share a highly conserved C-terminal alpha-crystallin domain, important for the modulation of both their structural and functional properties. HSPB proteins are biochemically classified as molecular chaperones and participate in protein quality control, preventing the aggregation of ...

2012
Toshiharu Sakurai Masatoshi Kudo Atsushi Umemura Guobin He Ahmed M. Elsharkawy Michael Karin

Most hepatocellular carcinomas (HCC) develop in the context of severe liver fibrosis and cirrhosis caused by chronic liver inflammation, which also results in accumulation of reactive oxygen species (ROS). In this study, we examined whether the stress-activated protein kinase p38a (Mapk14) controls ROS metabolism and development of fibrosis and cancer in mice given thioacetamide to induce chron...

Journal: :The Journal of biological chemistry 2004
Xiankui Sun Jean-Marc Fontaine Joshua S Rest Eric A Shelden Michael J Welsh Rainer Benndorf

Mammalian small heat shock proteins (sHSP) are abundant in muscles and are implicated in both muscle function and myopathies. Recently a new sHSP, HSP22 (HSPB8, H11), was identified in the human heart by its interaction with HSP27 (HSPB1). Using phylogenetic analysis we show that HSP22 is a true member of the sHSP superfamily. sHSPs interact with each other and form homo- and hetero-oligomeric ...

2017
Chun-Mei Wang Yan-You Pan Ming-Hui Liu Bao-Hua Cheng Bo Bai Jing Chen

Orexin-A is a neuropeptide with potent neuroprotective activity towards cerebral ischemia-reperfusion (I/R) injury, but few studies have attempted to elucidate the mechanism. Herein, we performed global gene expression profiling of the hippocampus following reperfusion with Orexin-A using RNA sequencing (RNA-seq). RNA-seq identified 649 differentially expressed genes (DEGs) in the Orexin-A grou...

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