نتایج جستجو برای: hsp70 heat shock proteins

تعداد نتایج: 815112  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Zarah Batulan Gayle A Shinder Sandra Minotti Bei Ping He Mohammad M Doroudchi Josephine Nalbantoglu Michael J Strong Heather D Durham

Heat shock protein 70 (Hsp70) protects cultured motor neurons from the toxic effects of mutations in Cu/Zn-superoxide dismutase (SOD-1), which is responsible for a familial form of the disease, amyotrophic lateral sclerosis (ALS). Here, the endogenous heat shock response of motor neurons was investigated to determine whether a high threshold for activating this protective mechanism contributes ...

Journal: : 2021

The presence of human immunodeficiency virus (HIV) as a cause acquired remains medical and social problem despite the success antiretroviral therapy. Heat shock proteins (heat-shock - HSP) are family produced by cells in response to stressful conditions. aim study was determine activity heat endometrium HIV infection. Research groups were formed with 25 cases each group: group infection, combin...

2009
Michael Roth Jun Zhong Michael Tamm John Szilard

Therapy with hyperthermal chemotherapy in pleural diffuse malignant mesothelioma had limited benefits for patients. Here we investigated the effect of heat stress on heat shock proteins (HSP), which rescue tumour cells from apoptosis. In human mesothelioma and mesothelial cells heat stress (39-42 degrees C) induced the phosphorylation of two mitogen activated kinases (MAPK) Erk1/2 and p38, and ...

2011
David G. Garbuz Lubov N. Astakhova Olga G. Zatsepina Irina R. Arkhipova Eugene Nudler Michael B. Evgen'ev

Heat shock protein 70 (Hsp70) is a molecular chaperone providing tolerance to heat and other challenges at the cellular and organismal levels. We sequenced a genomic cluster containing three hsp70 family genes linked with major histocompatibility complex (MHC) class III region from an extremely heat tolerant animal, camel (Camelus dromedarius). Two hsp70 family genes comprising the cluster cont...

2017
Myungsun Shin Andrew McGowan Gabriel J. DiNatale Thanprakorn Chiramanewong Tianyi Cai Rebecca E. Connor

The electrophilic natural product parthenolide has generated significant interest as a model for potential chemotherapeutics. Similar to other α,β-unsaturated carbonyl electrophiles, parthenolide induces the heat shock response in leukemia cells, potentially through covalent adduction of heat shock proteins. Other thiol-reactive electrophiles have also been shown to induce the heat shock respon...

2011
Elisa Zorzi Paolo Bonvini

Understanding the mechanisms that control stress is central to realize how cells respond to environmental and physiological insults. All the more important is to reveal how tumour cells withstand their harsher growth conditions and cope with drug-induced apoptosis, since resistance to chemotherapy is the foremost complication when curing cancer. Intensive research on tumour biology over the pas...

Journal: :American journal of physiology. Cell physiology 2006
Parvaneh Rafiee Monica E Theriot Victoria M Nelson Jan Heidemann Yasmin Kanaa Scott A Horowitz Aaron Rogaczewski Christopher P Johnson Irshad Ali Reza Shaker David G Binion

The heat shock response maintains cellular homeostasis following sublethal injury. Heat shock proteins (Hsps) are induced by thermal, oxyradical, and inflammatory stress, and they chaperone denatured intracellular proteins. Hsps also chaperone signal transduction proteins, modulating signaling cascades during repeated stress. Gastroesophageal reflux disease (GERD) affects 7% of the US populatio...

Journal: :The Journal of biological chemistry 2006
Tianyan Gao Alexandra C Newton

Heat shock proteins play important roles in regulating signal transduction in cells by associating with, and stabilizing, diverse signaling molecules, including protein kinases. Previously, we have shown that heat shock protein Hsp70 associates with protein kinase C (PKC) via an interaction that is triggered by dephosphorylation at the turn phosphorylation motif. Here we have identified an inva...

Journal: :Journal of immunology 2010
Jianlin Gong Yunfei Zhang John Durfee Desheng Weng Chunlei Liu Shigeo Koido Baizheng Song Vasso Apostolopoulos Stuart K Calderwood

In previous studies, we have shown that heat shock protein 70-peptide complexes (HSP70.PCs) derived from the fusion of dendritic cells (DCs) to tumor cells (HSP70.PC-F) possess superior properties compared with HSP70.PCs from tumor cells. HSP70.PC-F are more effective in stimulation of DC maturation and induction of CTL that are able to provide protection of mice against challenge with tumor ce...

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