نتایج جستجو برای: hsp25

تعداد نتایج: 193  

2014
Hirofumi Fujita Hanako Aoki Itsuki Ajioka Maya Yamazaki Manabu Abe Arata Oh-Nishi Kenji Sakimura Izumi Sugihara

Aldolase C (Aldoc, also known as "zebrin II"), a brain type isozyme of a glycolysis enzyme, is expressed heterogeneously in subpopulations of cerebellar Purkinje cells (PCs) that are arranged longitudinally in a complex striped pattern in the cerebellar cortex, a pattern which is closely related to the topography of input and output axonal projections. Here, we generated knock-in Aldoc-Venus mi...

Journal: :American journal of physiology. Renal physiology 2010
Madhavi J Rane Ye Song Shunying Jin Michelle T Barati Rui Wu Hina Kausar Yi Tan Yuehui Wang Guihua Zhou Jon B Klein Xiaokun Li Lu Cai

Hyperglycemia induces p38 MAPK-mediated renal proximal tubular cell (RPTC) apoptosis. The current study hypothesized that alteration of the Akt signaling pathway by hyperglycemia may contribute to p38 MAPK activation and development of diabetic nephropathy. Immunoblot analysis demonstrated a hyperglycemia-induced increase in Akt phosphorylation in diabetic kidneys at 1 mo, peaking at 3 mo, and ...

Journal: :Journal of applied physiology 2013
Steven S Welc Thomas L Clanton Shauna M Dineen Lisa R Leon

Heat stroke (HS) induces a rapid elevation in a number of circulating cytokines. This is often attributed to the stimulatory effects of endotoxin, released from damaged intestine, on immune cells. However, parenchymal cells also produce cytokines, and skeletal muscle, comprising a large proportion of body mass, is thought to participate. We tested the hypothesis that skeletal muscle exhibits a ...

Journal: :Journal of the American Society of Nephrology : JASN 2003
Scott K Van Why Andrea S Mann Thomas Ardito Gunilla Thulin Sarah Ferris Megan A Macleod Michael Kashgarian Norman J Siegel

The purpose of the study was to determine whether Hsp27 interacts with actin and could protect against selected manifestations of injury from energy depletion in renal epithelia. LLC-PK1 cells were stably transfected to overexpress human Hsp27 tagged with green fluorescence protein (GFP). Transfected expression of the labeled Hsp27 did not reduce endogenous Hsp25 levels in the cells compared wi...

Journal: :Diabetes 2009
Anisha A. Gupte Gregory L. Bomhoff Russell H. Swerdlow Paige C. Geiger

OBJECTIVE Heat treatment and overexpression of heat shock protein 72 (HSP72) have been shown to protect against high-fat diet-induced insulin resistance, but little is known about the underlying mechanism or the target tissue of HSP action. The purpose of this study is to determine whether in vivo heat treatment can prevent skeletal muscle insulin resistance. RESEARCH DESIGN AND METHODS Male ...

2016
Anna Slawinska John C. Hsieh Carl J. Schmidt Susan J. Lamont

Acute heat stress requires immediate adjustment of the stressed individual to sudden changes of ambient temperatures. Chickens are particularly sensitive to heat stress due to development of insufficient physiological mechanisms to mitigate its effects. One of the symptoms of heat stress is endotoxemia that results from release of the lipopolysaccharide (LPS) from the guts. Heat-related cytotox...

2011
Juliane Proft Jamshid Faraji Jerrah C. Robbins Fabiola C. R. Zucchi Xiaoxi Zhao Gerlinde A. Metz Janice E. A. Braun

Parkinson's disease (PD) is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra and the aggregation of α-synuclein into Lewy bodies. Existing therapies address motor dysfunction but do not halt progression of the disease. A still unresolved question is the biochemical pathway that modulates the outcome of protein misfolding and aggregatio...

2010
Lisa Schwarz Grit Vollmer Christiane Richter-Landsberg

Filamentous tau-positive protein inclusions in neurons and glia are prominent features of a number of neurodegenerative disorders termed tauopathies. These inclusions are further characterized by the presence of heat shock proteins (HSPs). The group of small HSPs, namely, HSP27 and alphaB-crystallin, interact with the cytoskeleton, bind to nonnative proteins, and prevent their aggregation after...

2014
Robert C Barber David L Maass D Jean White Jureta W Horton Steven E Wolf Joseph P Minei Qun S Zang

Severe sepsis is a leading cause of death in intensive care units [1,2]. Despite improvements in antibiotic therapies and critical care techniques [3], approximately 215,000 Americans still die from sepsis each year [4]. Present treatment for sepsis continues to be supportive care and source control, such as using intravenous fluids and oxygen, and/or antibiotics and procedural interventions [3...

Journal: :Circulation research 2002
Ivor J Benjamin Elisabeth Christians

Acute ischemic injury and myocardial infarction arising from coronary artery disease, despite significant strides in medical and surgical management, remain a major public problem. Sex disparity has long been recognized for coronary ischemic events: premenopausal women are at reduced risk for atherosclerotic disease than men of similar age, an advantage that vanishes after menopause.1 The benef...

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