Hypothalamic-pituitary-adrenal (HPA) axis sensitivity was investigated in 32 non-medicated patients with borderline personality disorder without comorbid post-traumatic syndromes and in 18 normal individuals using a modified dexamethasone suppression test (0.25 mg). Enhanced cortisol suppression was found in the patients v. controls (P<0.05) and the percentage of participant's with non-suppress...

A 78-year-old Japanese man showed suppression of the hypothalamic-pituitary-adrenal axis during maximum androgen blockade (MAB) therapy including chlormadinone acetate (CMA) for prostate cancer. After stopping the MAB therapy, both the basal ACTH level and the response to CRH recovered. While no reports have indicated that CMA suppresses the hypothalamic-pituitary-adrenal axis in patients with ...

Abstract INTRODUCTION Over the past two decades, treatment of small-to-medium (&amp;lt; 3cm) sporadic vestibular schwannomas (VS) has experienced a definite shift to stereotactic radiosurgery vis-a-vis microsurgery. We performed systematic review and meta-analysis VS patients primarily treated with (SRS) or microsurgery (MS), particular attention hearing preservation outcomes (HPO), tumor contr...

BACKGROUND AND OBJECTIVE Hypothalamic-pituitary-adrenal axis suppression (HPAS) when treating children with corticosteroids is thought to be rare. Our objective was to determine the prevalence of and predictive factors for various degrees of HPAS. METHODS Clinical features of HPAS, doses, adherence, asthma score, and lung functions were recorded in 143 asthmatic children. The overnight metyra...

Halogenated natural products are frequently reported metabolites in marine seaweeds. These compounds span a range from halogenated indoles, terpenes, acetogenins, phenols, etc., to volatile halogenated hydrocarbons that are produced on a very large scale. In many cases these halogenated marine metabolites possess biological activities of pharmacological interest. Given the abundance of halogena...

The asymmetric unit of the title compound, 2C(10)H(18)N(+)·HPO(4) (2-)·1.5C(4)H(4)O(4), contains two adamantan-1-aminium cations, one hydrogen phosphate anion, and one and a half mol-ecules of fumaric acid, one of which exhibits crystallographic inversion symmetry. Each HPO(4) (2-) anion is hydrogen bonded, via all of its O atoms, to four NH(3) (+) groups of the adamantan-1-aminium cations, for...