Tablet dissolution is strongly affected by swelling and solvent penetration into its matrix. A terahertz-pulsed imaging (TPI) technique, in reflection mode, is introduced as a new tool to measure one-dimensional swelling and solvent ingress in flat-faced pharmaceutical compacts exposed to dissolution medium from one face of the tablet. The technique was demonstrated on three tableting excipient...

Breast cancer is the most prevalent cancer in American women. Dietary factors are thought to have a strong influence on breast cancer incidence. This study utilized a meal-feeding protocol with female Sprague-Dawley rats to evaluate effects of two ratios of carbohydrate:protein on promotion and early progression of breast tissue carcinomas. Mammary tumors were induced by N-methyl-N-nitrosourea ...

Hydroxypropyl methylcellulose (HPMC) was employed in this study to design controllable drug release systems because of its non-toxic nature, swelling properties. New interpenetrating polymer networks (IPN) of HPMC / tri-isocyanate crosslinked polyurethane (TCPU) could be prepared on the surfaces of IPN materials. To design "Novel Drug-carrying Matrix Systems", incorporation of novel structure i...

Antibiotic use is an essential method for the treatment of bacterial infections. In certain cases, antibiotics are not effective because of the distribution problems caused by physiological barriers in the body. Such problems are thought to be minimized by development of sustained release systems which involve implantation of antibiotic loaded polymeric systems directly to the site of infection...

本研究では，薬物非晶質ナノ粒子形成型固体分散体製剤（Amorphous solid dispersion: ASD）の開発および薬物非晶質ナノ粒子形成が薬物吸収性に及ぼす影響の定量的評価を行った．難水溶性モデル薬物としてfenofibrate（FFB），ポリマー担体としてhypromellose（HPMC）を用い，噴霧乾燥によりFFB/HPMC ASDを調製した．FFB/HPMC物理的混合物（Physical mixture: PM）懸濁液中では，μmオーダーのFFB結晶が分散していた一方，FFB/HPMC ASD懸濁液では非晶性の約160 nmのナノ粒子の形成が認められた．FFB/HPMC ASD懸濁液中に溶解したFFB濃度は，FFB/HPMC PM懸濁液と比較して約8.6倍高い値を示した．ラット小腸上皮細胞へのナノ粒子の取り込みを評価した結果，ナノサイズの非晶質FFB粒子が直接小...

In the present piece of research work focuses on grafting Acrylic acid with HPMC to obtain copolymers with improved properties, biodegradable and biocompatible that will be used as hydrogel or water absorbing polymers. To develop a prolong release activity drug delivery system for the medication purpose to enhance drug activity and reduce the frequency of dose via this hydrogel. A novel HPMC-ga...

We report on the preparation of a biopolymer thin film by hydroxypropyl methylcellulose (HPMC), which can be used as a dry green lubricant in sustainable manufacturing. The thin films were characterized through scanning electron microscopy, energy-dispersive spectroscopy, and Raman spectroscopy; the films showed desirable levels of thickness, controllability, and uniformity. Tribology tests als...

In the present work, monolithic matrix transdermal systems containing Drug x were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl citrate as a plasticizer. A 32 full factorial design was employed. The concentration of HPMC and ES were used as independent variables, while percentage drug release was selected as d...

Sustained release drug delivery systems are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum utilization of the drug, increased...

Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...