Buccoadhesive tablets of carvedilol were prepared using HPMC K4M, HPMC K15M and Carbopol 934 as mucoadhesive polymers. Fifteen formulations were developed with varying concentrations of polymers. Formulations of the BC or BD series were composed of HPMC K4M or HPMC K15M in ratios of 1:1 to 1:5 whereas in the BE series Carbopol 934 was used (1:0.25 to 1:1.50). The formulations were tested for in...

本研究では，薬物非晶質ナノ粒子形成型固体分散体製剤（Amorphous solid dispersion: ASD）の開発および薬物非晶質ナノ粒子形成が薬物吸収性に及ぼす影響の定量的評価を行った．難水溶性モデル薬物としてfenofibrate（FFB），ポリマー担体としてhypromellose（HPMC）を用い，噴霧乾燥によりFFB/HPMC ASDを調製した．FFB/HPMC物理的混合物（Physical mixture: PM）懸濁液中では，μmオーダーのFFB結晶が分散していた一方，FFB/HPMC ASD懸濁液では非晶性の約160 nmのナノ粒子の形成が認められた．FFB/HPMC ASD懸濁液中に溶解したFFB濃度は，FFB/HPMC PM懸濁液と比較して約8.6倍高い値を示した．ラット小腸上皮細胞へのナノ粒子の取り込みを評価した結果，ナノサイズの非晶質FFB粒子が直接小...

In the present piece of research work focuses on grafting Acrylic acid with HPMC to obtain copolymers with improved properties, biodegradable and biocompatible that will be used as hydrogel or water absorbing polymers. To develop a prolong release activity drug delivery system for the medication purpose to enhance drug activity and reduce the frequency of dose via this hydrogel. A novel HPMC-ga...

We report on the preparation of a biopolymer thin film by hydroxypropyl methylcellulose (HPMC), which can be used as a dry green lubricant in sustainable manufacturing. The thin films were characterized through scanning electron microscopy, energy-dispersive spectroscopy, and Raman spectroscopy; the films showed desirable levels of thickness, controllability, and uniformity. Tribology tests als...

Sustained release drug delivery systems are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum utilization of the drug, increased...

Silver ion has been used for centuries to prevent and treat a variety of diseases and infections. In recent years, extensive studies have been undertaken on the use of antimicrobial properties of silver, incorporated within medical devices. The aim of this study was to prepare a formulation containing silver ion, which could be applied for wound dressing. The purity of nanosilver was measured b...

Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

The effect of stabilizer type (small molecule vs. polymeric) and the amount of micellar solubilized drug on Ostwald ripening of nanosuspensions was investigated. Indomethacin nanosuspensions were prepared with small molecule stabilizers (sodium lauryl sulfate (SLS) and Dowfax 2A1 (DF)) and a polymeric stabilizer (hydroxypropyl methyl cellulose (HPMC)). Two different drug:stabilizer ratios were ...

Interaction of the antipsychotic drug risperidone with hydroxypropyl-beta-cyclodextrin (HPBCD) in solution and in the solid state was studied with the aim of overcoming the limitations associated with nasal administration of low solubility drugs. Risperidone solubility studies revealed inclusion complex formation with a 1:1 stoichiometry. Low concentrations (0.1 w/v %) of hydroxypropylmethyl ce...