The aim of our study was to identify factors affecting the in vitro release diclofenac sodium (DS) from hypromellose-based gels (HPMC).
 Materials and methods. Gels with HPMC liquids without were studied by viscosity-rotating viscometer method spin probe electron paramagnetic resonance spectroscopy. Rheograms used determine flow behavior apparent viscosity, EPR spectra rotational correlati...

The purpose of this study was formulation and in vitro evaluation of floating-bioadhesive tablets to lengthen the stay of glipizide in its absorption area. Effervescent tablets were made using chitosan (CH), hydroxypropyl methylcellulose (HPMC), carbopolP934 (CP), polymethacrylic acid (PMA), citric acid, and sodium bicarbonate. Tablets with 5% effervescent base had longer lag time than 10%. The...

INTRODUCTION Hydrophilic matrices represent a popular and widely used approach for oral extended release (ER) drug delivery. Hypromellose (HPMC) remains the polymer of choice as the release rate-controlling component. In addition to HPMC, polyethylene oxide (PEO) has been extensively studied as a matrix-forming polymer. This is mainly attributed to its availability in a range of molecular weigh...

Floating matrix tablets of Cephalexin were prepared by using synthetic and natural polymers each in two different concentrations. The floating properties and in-vitro drug release properties were optimized and total 10 formulations were developed. The synthetic and natural polymers used were HPMC K4M, HPMC K15M and Guar Gum, Xanthan gum respectively. Each formulation consists of polymer in any ...

The work aimed at developing a modified release hydrogel formulation of poorly soluble drug, Gliclazide using a retardant hydrophilic polymer HPMC in two grades i.e., HPMC 15 cps and Methocel K4M. All six formulations were developed and evaluated for the in-vitro drug release up to 16hrs and compared with that of the marketed formulation. GMF VI was found to have similar release pattern proving...

Fast dissolving film of levocetrizine dihydrochloride were prepared by solvent casting method by using Maltodextrin & HPMC E15 as the main film forming polymers.To decrease the disintegration time,concentration of maltodextrin & HPMC E15 were optimized be using 2 factorial design. Disintegration time, drug release pattern, mouth dissolving time and content uniformity were also evaluated. Compat...

in order to determine the control of breeding sources of culex larvae in sewage wells by the larvicide abate, some studies were performed in the summer and autumn of 1972. in general, it was noticed in these studies that:1. the wells chosen as a control (5 wells) were active throughout the study periods and adult mosquitoes were captured plentifully. 2 in 4 sewage wells which were controlled by...

Nasal solutions of almotriptan malate were prepared in phosphate buffer containing different proportions of HPMC E15. In vitro permeation studies were performed using Franz diffusion cell with dialysis membrane and ex vivo permeation studies were carried out using sheep nasal mucosal layer. The formulations were radiolabeled with 99mTc and the nasal residence time was studied in rabbits. Nasal ...

Primary dermal and eye irritation tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether), a new cellulose derivative used as a thickener for topical pharmaceuticals and cosmetics, were conducted in rabbits. A dispersion of HM-HPMC (3%) was applied to intact and abraded skins and reactions were observed. A very ...

background the dilution and rapid elimination of topically applied drugs due to the flushing action of saliva is a major difficulty in the effort to eradicate infections of oral cavity. utilization a proper delivery system for incorporation of drugs has a major impact on drug delivery and such a system should be formulated for prolonged drug retention in oral cavity. objectives the aim of the p...