regardless of severity, earlier intervention to correct hearing loss in children improves speech development and conversational abilities. a cross-sectional study was performed on 230 neonates who were at risk of hearing loss in tehran university of medical sciences hospitals between september 2000 and february 2002. hearing was examined before the 3rd month by auditory brainstem responses (abr...

Schizophrenia is characterised by generalised cognitive impairment that is both a risk factor and a predictor of outcome. Recent research into human intelligence supports the view that, in schizophrenia, poor performance on disparate cognitive tasks can be explained by dysfunction of a frontoparietal neural network thought to support fluid intelligence.

People with schizophrenia die prematurely. Their illness, its treatment and their lifestyle all contribute to the excess morbidity and mortality. Lifestyle ‘choices’ (e.g. poor diet, low rates of physical activity and increased likelihood to smoke cigarettes) predispose them to poor physical health and comorbid medical diseases. In addition, weight gain and obesity are a consequence of most ant...

OBJECTIVE It is well known that advancing paternal age is associated with an increased risk of schizophrenia in offspring, but the mechanism behind this association remains unknown. This study investigates if delayed fatherhood rather than advancing paternal age per se might explain the increased risk of schizophrenia in offspring associated with advancing paternal age. METHODS This is a regi...

Introduction: There are several hypotheses of schizophrenia pathogenesis, including the neurodegenerative theory, which is supported by evidence for decrease neuroprotective factors’ serum levels. The proteins, that exert a protective effect on neurons and researched concerning include brain-derived neurotrophic factor (BDNF), nerve growth (NGF), neurotrophin 3 (NT3), glial cell line-derived (G...

The purpose of this review is to summarize the current state of knowledge on how nongenetic factors occurring before, during, or soon after birth are related to schizophrenia. Schizophrenia is a complex psychiatric illness with a varied clinical presentation that has both environmental and genetic origins and that may result from insults to the nervous system that occur throughout development. ...

Numerous studies have evaluated the association between Ser311Cys (rs1801028, C>G) polymorphism of the dopamine D2 receptor (DRD2) gene and schizophrenia risk. However, the specific association is still controversial. We examined whether DRD2 Ser311Cys polymorphism confers schizophrenia risk in Asian populations. Sixteen studies were retrieved reporting on a total of 2268 schizophrenia pa...

background: a recent study at the maroua provincial hospital revealed that hypertension in pregnancy was the first cause of maternal death, representing 17.5% of the 63 maternal deaths recorded between 2003 and 2005. knowing little about the causes, this study was to identify the possible risk factors for hypertensive disorders in pregnancy. methods: this case-control study was-done at the maro...

schizophrenia is a complex disorder with polygenic inheritance. the mthfr gene (omim: 607093) plays an important role in the folate metabolism. it has been suggested that c677t (rs1801133) and a1298c (rs1801131) genetic polymorphisms in the mthfr gene lead to the decreased activity of the methylenetetrahydrofolate reductase enzyme which may have significant effect on developing schizophrenia. w...

To review the available Real World Data (RWD) demonstrating comparative advantages of newer LAIs over oral antipsychotics (OAPs) in Schizophrenia with respect to relapse, hospitalization, and economic outcomes. A systematic literature (2000- present) was done by two reviewers searching Embase, PubMed/Medline, EBSCO, PsycINFO, ScienceDirect, Cochrane Library databases. Search terms screening cri...