Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulling along disjoined sister chromatids, thereby contributing to chromosome segregation and the propagation of all cellular life. The major biochemical "modules" that cooperate to mediate pole-pole separation include: (i...

Hepatitis-associated aplastic anemia (HAA) is a syndrome of bone marrow failure following an acute attack of seronegative hepatitis. Clinical features and liver histology suggest a central role for an immune-mediated mechanism. To characterize the immune response, we investigated the T-cell repertoire (T-cell receptor [TCR] V(beta) chain subfamily) of intrahepatic lymphocytes in HAA patients by...

Toxicologic studies have demonstrated associations between growth-related birth outcomes and exposure to high concentrations of disinfection by-products (DBPs), including specific trihalomethane (THM) and haloacetic acid (HAA) chemical subspecies. Few prior investigations of DBPs have evaluated exposure during the third trimester of pregnancy, the time period of gestation when fetal growth may ...

Biodegradation is a potentially important loss process for haloacetic acids (HAAs), a class of chlorination byproducts, in water treatment and distribution systems, but little is known about the organisms involved (i.e., identity, substrate range, biodegradation kinetics). In this research, 10 biomass samples (i.e., tap water, distribution system biofilms, and prechlorinated granular activated ...

The spatial distribution of saturated areas is an important consideration in numerous applications, such as water resource planning or sighting of management practices. However, in humid well vegetated climates where runoff is produced by saturation excess processes on hydrologically active areas (HAA) the delineation of these areas can 5 be difficult and time consuming. Much of the non-point s...

AND YUEFENG F. XIE aloacetic acids (HAAs) are a group of disinfection by-products (DBPs) regulated under the Stage 1 Disinfectants/Disinfection Byproducts Rule (D/DBPR). The maximum contaminant level for five HAAs is 60 μg/L. These five regulated HAAs are monochloroacetic acid (ClAA), dichloroacetic acid (Cl2AA), trichloroacetic acid (Cl3AA), monobromoacetic acid (BrAA), and dibromoacetic acid ...

A subset of H2M3wt-restricted, Listeria monocytogenes (LM)-immune CD8 effectors recognize antigen-presenting cells (APC) preincubated with heat-killed LM. The responsible product, which we have previously designated heat-killed Listeria-associated antigen (HAA), is extremely hydrophobic and resistant to proteolytic degradation. Despite the protease resistance of HAA, we now report that HAA-immu...

By John M stts M aybe tea leaves, a c rysta l ball or horoscope could have done th e trick I No hum an fo resig h t was skillful enough to determ ine th e re would be a downfall of Cal Poly 's Rally com­ m ittee . I ts 10 o r 12 m em bers have alm ost stopped try ing.' H ere is w hat a week-long investiga tion revealed. W hat has happened to Cal Poly's rally com -t m litas could happen to any o...

An innovative haloacetic acid (HAA) removal process was developed. The process consisted of a zero-valent iron (Fe(0)) column followed by a biologically active carbon (BAC) column that were efficient in degrading tri- and di-HAAs, and mono- and di-HAAs, respectively. The merit of the process was demonstrated by its performance in removing trichloroacetic acid (TCAA). An empty bed contact time o...

BACKGROUND Although serum under-O-glycosylated IgA1 in IgA nephropathy (IgAN) patients may deposit more preferentially in glomeruli than heavily-O-glycosylated IgA1, the relationship between the glomerular IgA deposition level and the O-glycan profiles of serum IgA1 remains obscure. METHODS Serum total under-O-glycosylated IgA1 levels were quantified in 32 IgAN patients by an enzyme-linked im...