conclusions hcv gpe2 is an ideal target for hcv vaccine. prediction of epitope immunogenicity and characterization on the basis of peptide sequences will be significantly helpful for development of a heterologous vaccine against hcv variants. results many b-cell and t-cell epitopes predicted in gpe2 were found conserved among hcv 3a genotypes whereas few were conserved in other genotypes antici...

background: the number of reported cases, infected with carbepenem resistant acinetobacter baumannii (crab) and multi-drug resistant (mdr) acinetobacter species had gradually increased in most pla general hospital wards from april to june in 2007. objectives: we have described the investigation of an outbreak of crab and mdr acinetobacter in pla general hospital, beijing. the prospective and re...

Given a Heegaard splitting of a three-manifold Y , we consider the SL(2,C) character variety of the Heegaard surface, and two complex Lagrangians associated to the handlebodies. We focus on the smooth open subset corresponding to irreducible representations. On that subset, the intersection of the Lagrangians is an oriented d-critical locus in the sense of Joyce. Bussi associates to such an int...

In this paper, we formalize the notion of λ-AT-model (where λ is a non-null integer) for a given chain complex, which allows the computation of homological information in the integer domain avoiding using the Smith Normal Form of the boundary matrices. We present an algorithm for computing such a model, obtaining Betti numbers, the prime numbers p involved in the invariant factors of the torsio...

A chain complex model for the free loop space of a connected compact oriented manifold is presented. Some algebraic operations on such a chain complex are studied, and on its homology, the Gerstenhaber and Batalin-Vilkovisky algebra structures are proven. The gravity algebra on the equivariant homology of the free loop space is also constructed. This gives an algebraic and chain level model of ...

A chain complex model for the free loop space of a connected, closed and oriented manifold is presented, and on its homology, the Gerstenhaber and Batalin-Vilkovisky algebra structures are defined and identified with the string topology structures. The gravity algebra on the equivariant homology of the free loop space is also modeled. The construction includes the non-simply connected case, and...

A simply connected topological space X has homotopy Lie algebra ( X) Q. Following Quillen, there is a connected di erential graded free Lie algebra (dgL) called a Lie model, which determines the rational homotopy type of X , and whose homology is isomorphic to the homotopy Lie algebra. We show that such a Lie model can be replaced with one that has a special property we call separated. The homo...

A theoretical model of human Janus kinase 2 (JAK2) comprising all seven Janus homology domains is presented. The model was generated by application of homology modelling approaches. The three-dimensional structure contains, starting from the N-terminus, FERM (4.1, ezrin, radixin, moesin), SH2 (Src homology region 2), tyrosine kinase-like, and tyrosine kinase domains. The predicted inter-domain ...

Internet Electronic Conference of Molecular Design 2004, November 29 – December 12 Abstract Motivation. Theoretical prediction of protein structures is important because the number of sequenced proteins grows much faster than the number of experimentally determined 3D structures. Among theoretical methods, homology or comparative modeling of unknown 3D protein structures (targets) has been esta...

An important step in the calculation of the triply graded link theory of Khovanov and Rozansky is the determination of the Hochschild homology of Soergel bimodules for SL(n). We present a geometric model for this Hochschild homology for any simple group G, as equivariant intersection homology of B × Borbit closures in G. We show that, in type A these orbit closures are equivariantly formal for ...