The mouse Lyt-1, Lyt-2, and Lyt-3 lymphocyte surface antigens have been used for some years now as immunogenet ic markers whose selective expression distinguishes maturat ional and functional T cell subpopulations (1, 2). Lyt-2 and Lyt-3, for example, are selectively expressed on cytotoxic and suppressor T cells but are not found on helper T cells (3, 4). Similarly, cytotoxic depletion studies ...

Purpose: Hallmarks of germline BRCA1/2-associated ovarian carcinomas include chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 mutations and mutations in other homologous recombination DNA repair genes is uncertain. Experimental Design: Using targeted capture and massively parallel genomic sequencing, we assessed 390ovarian carcinomas for germline and somatic los...

Immunoglobulin kappa (IGK) and immunoglobulin lambda (IGL) light chain repertoire was analyzed in 276 chronic lymphocytic leukemia (CLL) cases and compared with the relevant repertoires from normal, autoreactive, and neoplastic cells. Twenty-one functional IGKV genes were used in IGKV-J rearrangements of 179 kappa-CLL cases; the most frequent genes were IGKV3-20(A27), IGKV1-39/1D-39(O2/O12), IG...

PURPOSE Hallmarks of germline BRCA1/2-associated ovarian carcinomas include chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 mutations and mutations in other homologous recombination DNA repair genes is uncertain. EXPERIMENTAL DESIGN Using targeted capture and massively parallel genomic sequencing, we assessed 390 ovarian carcinomas for germline and somatic lo...

A new homologous series of linear aliphatic polyesters, such as poly (cis-2- butenylene carboxylate)S, PBms (m is the number of methylene groups in the acid component, m=2-8 have been synthesized by direct polyesterification reactions in anisole, as solvent. FT-IR, 400 MHz H- NMR, C-NMR and elemental analysis were used to establish the structure of polyesters. Molecular weight distributi...

We show that a complete [Formula: see text]-dimensional Riemannian manifold text] with finitely generated first homology has macroscopic dimension if it satisfies the following “macroscopic curvature” assumptions: every ball of radius in volume at most text], and loop is null-homologous concentric text].

background and objectives : 300 pseudomonas aeruginosa strains were isolated from hospitalized patients in iran. using international antigenic typing system (iats) antibodies, all strains were classified into 16 serotypes while serotype 14 was not identified among the 17 known serotypes. to evaluate the rate of cross-reactivity between o- antigenic determinants, monospecific polyclonal antibodi...

Homologous recombination plays essential roles in mitotic DNA double strand break (DSB) repair and meiotic genetic recombination. In eukaryotes, RAD51 promotes the central homologous-pairing step during homologous recombination, but is not sufficient to overcome the reaction barrier imposed by nucleosomes. RAD54, a member of the ATP-dependent nucleosome remodeling factor family, is required to ...

In recombinational DNA double-strand break repair a homologous template for gene conversion may be located at several different genomic positions: on the homologous chromosome in diploid organisms, on the sister chromatid after DNA replication, or at an ectopic position. The use of the homologous chromosome in mitotic gene conversion is thought to be limited in the yeast Saccharomyces cerevisia...