BACKGROUND Dyslipidemia is a key factor determining the development of both myocardial infarction (MI) and its subsequent complications. Dyslipidemia is associated with endothelial dysfunction, activation of inflammation, thrombogenesis, and formation of insulin resistance. Statin therapy is thought to be effective for primary and secondary prevention of complications associated with atheroscle...

OBJECTIVE To explore the correlations between liver fat content and clinical index in patients with impaired glucose tolerance (IGT) and healthy subjects. MATERIALS AND METHODS 56 subjects were enrolled and each of them underwent upper-abdominal MRI examination that involved a T1 VIBE Dixon sequence. 14 was clinically diagnosed with IGT (collectively as IGT group ) while 42 showed normal gluc...

OBJECTIVES To identify the fasting glucose/leptin ratio as a new simple method for the detection of insulin resistance in Iraqi diabetes mellitus patients, and to examine its usefulness as a new marker for insulin resistance. METHODS A case control study conducted at the National Diabetes Center, College of Medicine at Al-Mustansiryia University from 1 August 2008 to 30 January 2010. An enzym...

INTRODUCTION Obesity-related comorbidities are present in young obese children, providing a platform for early adult cardiovascular disorders. OBJECTIVES To compare and correlate markers of adiposity to metabolic disturbances, vascular and cardiac morphology in a European pediatric obese cohort. METHODS We carried out an observational and transversal analysis in a cohort consisting of 121 o...

I t was good to see the interesting article by Bergenstal et al. (1), from both academic and commercial colleagues, of a novel approach to a long-acting insulin (LY2605541), possibly hepatospecific, as studied in individuals with type 2 diabetes. Both alanine aminotransferase (ALT) and serum triglycerides were higher compared with a standard insulin comparator, whereas body weight trajectory wa...

BACKGROUND Insulin resistance (IR) correlates closely with cardiovascular disease. C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that modulates insulin activity in various diseases. This study investigated the relationship between CTRP3 and IR as well as systemic inflammation in newly diagnosed obese and hypertensive patients (NCT02226471). METHODS Serum CTRP3 levels, anthropometric,...

Oxidative stress is a major risk factor in the onset and progression of type 2 diabetes mellitus (T2DM). NF-E2 related factor 2 (NRF2) is a pivotal transcription factor in oxidative stress related illnesses. This study included 2174 subjects with 879 cases of newly-diagnosed T2DM and 1295 healthy controls. Compared to individuals with the CC genotype, those with the AA genotype had lower total ...

OBJECTIVE The extent to which abnormal glucose metabolism increases the risk of depression remains unclear. In this study, we investigated prospective associations of levels of fasting glucose and fasting insulin and indices of insulin resistance and secretion with subsequent new-onset depressive symptoms (DepS). RESEARCH DESIGN AND METHODS In this prospective cohort study of 3,145 adults fro...

OBJECTIVE To evaluate the effect of dipeptidyl-peptidase-4 (DPP-4) inhibitor vildagliptin on high sensitivity C-reactive protein (hsCRP) and arterial stiffness (AS) in patients with type 2 diabetes (T2DM). DESIGN Sixty-four drug-naive diabetic patients, with inadequate glycemic control, participated in this randomized, open-label study. Half of the patients received metformin 1700 mg/d and th...

OBJECTIVE To evaluate the effects of periodontal intervention on inflammatory cytokines, adiponectin, insulin resistance (IR), and metabolic control and to investigate the relationship between type 2 diabetes mellitus (T2DM) and moderately poor glycemic control and chronic periodontitis. METHODS AND PATIENTS A total of 190 moderately poorly controlled (HbA1c between 7.5% and 9.5%) T2DM patien...