Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched controls (n = 10; mean age = 7.55 +/- 1.32) using indirect insulin resistance parameters. Two groups wer...

OBJECTIVE The goal of this study was to evaluate the performance of surrogate measures of insulin sensitivity and insulin secretion. RESEARCH DESIGN AND METHODS The homeostasis model assessment (HOMA) of insulin resistance (IR) and the insulin sensitivity index (S(i)) from oral glucose tolerance test (OGTT) were compared with the M value from a hyperinsulinemic-euglycemic clamp in 467 subject...

Background: Despite thyroid nodules mostly have benign nature, there are always malignancy risks. Therefore, understanding the mechanisms influencing this potential malignant transformation is highly important in cancer prevention strategies. We aimed case-control study to investigate relationship of anthropometric parameters, and insulin resistance with risk nodular patients. Methods: This sin...

OBJECTIVE Branched-chain and aromatic amino acids are associated with the risk for future type 2 diabetes; however, the underlying mechanisms remain elusive. We tested whether amino acids predict insulin resistance index in healthy young adults. RESEARCH DESIGN AND METHODS Circulating isoleucine, leucine, valine, phenylalanine, tyrosine, and six additional amino acids were quantified in 1,680...

BACKGROUND The present study aimed to determine the most efficient insulin resistance function related to glycemic control expressed as glycated hemoglobin (HbA1c) in type 2 diabetes mellitus patients (T2DM). The other aim is to derive equations for the prediction of beta cell functions containing HbA1c as a parameter in addition to fasting glucose and insulin. METHODS T2DM Patients were grou...

OBJECTIVE The aim of the present study was to clarify the significance of high levels of high-density lipoprotein cholesterol (HDL-C) in Japanese women receiving an annual health check-up. METHODS A total of 1879 women who were not taking medication for hypertension, diabetes or dyslipidemia, with no prior history of ischemic heart disease, cerebrovascular disease or chronic renal failure wer...

INTRODUCTION Insulin resistance (IR) is common in patients with nonalcoholic fatty liver disease (NAFLD). We compared the performance of insulin tolerance test and the homeostasis model assessment (HOMA) for measuring IR in such patients. METHODS In a prospective study, IR was determined using both insulin tolerance test and HOMA in 22 patients with NAFLD. Rate constant for insulin tolerance ...

objective: vitamin d appears to be involved in regulation of glycemic and inflammatory responses in gestational diabetes. the purpose of this study was to compare the serum levels of 25-hydroxyvitamin d (25(oh)d), inflammatory biomarkers and glycemic profile between gestational diabetes mellitus (gdm) and normal glucose tolerance (ngt) pregnant women. materials and methods: in this cross-sectio...

PURPOSE: Postmenopausal status is associated with an age-related decline in hormones, abnormal appetite regulation, weight gain, and increased risk of cardiovascular disease (CVD). Exercise a useful non-pharmacological intervention that improves the levels hormones involved regulation management while reducing CVD factors. The present study aimed to elucidate effect ballet program on menopause-...