We have recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on chromosome 20q13.13-13.2. There is considerable overlap of clinical features of Okihiro syndrome with other conditions, most notably Holt-Oram syndrome, a condition in part resulting from mutation of the TBX5 locus, as well as acro-renal-ocular syndrome. We analysed ...

The U.S. Census Bureau has developed SPEER software that applies the Fellegi-Holt editing method to economic establishment surveys under ratio edit and a limited form of balancing. It is known that more than 99% of economic data only require these basic forms of edits. If implicit edits are available, then Fellegi-Holt methods have the advantage that they determine the minimal number of fields ...

Abstract Covid-19 has spread throughout the world, including in Indonesia and it is known that virus reported to be highly contagious. fourth-largest population for cases Asia, while world top three covid-19 are United States, Brazil, India, so inevitable, will greatly felt of pandemic coronavirus, even estimated freed from coronavirus a shorter period when compared other countries with less ex...

This paper examines the relation between adjustment patterns and equilibrium selection in laboratory experiments with two types of simple signaling games. One type of game has two Nash equilibria, of which only one is sequential. The other type has two sequential equilibria, only one of them satisfying equilibrium dominance. For each type of game, the results show that variations in the payoff ...

Heterozygous Tbx5(del/+) mice were generated to study the mechanisms by which TBX5 haploinsufficiency causes cardiac and forelimb abnormalities seen in Holt-Oram syndrome. Tbx5 deficiency in homozygous mice (Tbx5(del/del)) decreased expression of multiple genes and caused severe hypoplasia of posterior domains in the developing heart. Surprisingly, Tbx5 haploinsufficiency also markedly decrease...

In 2004, the UK Government’s Department for Environment, Food and Rural Affairs (DEFRA) commissioned research with the objective of developing a scheme for assessing the risks posed to species, habitats and ecosystems in the UK by nonnative organisms. The outcome was the UK Non-Native Organism Risk Assessment Scheme . A comprehensive overview of the risk assessment methodology and its applicati...

This article presents three methods to forecast accurately the amount of traffic in TCP=IP based networks: a novel neural network ensemble approach and two important adapted time series methods (ARIMA and Holt-Winters). In order to assess their accuracy, several experiments were held using real-world data from two large Internet service providers. In addition, different time scales (5min, 1 h a...