Background Alcohol consumed in large quantities for many years has long been recognized to induce an alcoholic cardiomyopathy. Clinically identical to idiopathic dilated cardiomyopathy, alcoholic cardiomyopathy is a major form of secondary dilated cardiomyopathy in the Western world. (See Medscape Reference articles Alcoholic Cardiomyopathy and Dilated Cardiomyopathy.) With this change in cardi...

Major European tour operator groups have been developing and installing new systems and corporate networks as well as links between these and other information and reservation systems in the travel and tourism industry during the most recent years. It is argued that these new system strategies are a key part of overall strategies to re-engineer their business activities both in the production a...

Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses. We appreciated the article by ROSSI et al. [1] entitled " Is continuous positive airway pressure necessarily an everyday therapy in patients with obstructive sleep apnoea? " , as well as the corresponding editorial [2], recently published in t...

North Wales is one of the most beautiful spots to visit for a short break, particularly in the early spring. In fact, the local population swells by 50 per cent in the peak holiday season.

BACKGROUND International travellers are at a risk of infectious diseases not seen in their home country. Stomach upsets are common in travellers, including on cruise ships. This study compares the incidence of stomach upsets on land- and cruise-based holidays. METHODS A major British tour operator has administered a Customer Satisfaction Questionnaire (CSQ) to UK resident travellers aged 16 o...

Background The seasonality of influenza is thought to vary according to environmental factors and human behavior. During winter holidays, potential disease-causing contact and travel deviate from typical patterns. We aim to understand these changes on age-specific and spatial influenza transmission. Methods We characterized the changes to transmission and epidemic trajectories among children ...

In this paper we assess the appeal of potential interventions on the tourism offer of Rimini, a popular Italian seaside holiday destination, by means of a choice modelling analysis. Tourism can be viewed as a composite good, its overall utility depending on the arrangement of the component characteristics. Our discrete choice experiments incorporate as attributes a number of possible changes to...

Background. The seasonality of influenza is thought to vary according to environmental factors and human behavior. During winter holidays, potential disease-causing contact and travel deviate from typical patterns. We aim to understand these changes on age-specific and spatial influenza transmission. Methods. We characterized the changes to transmission and epidemic trajectories among children ...

Comment. In Goodpasture syndrome or anti-GBM nephritis, advanced renal impairment is not generally prevented by current treatments when the patient presents initially with Source Haemodialysis CAPD/ Transplant Total progressive renal insufficiency. Here we used cyclosporin A, IPD which is commonly used in organ transplantation, because of its selective inhibition of immune response. The immuno-...

Energy shortage and atmospheric pollution problems are getting more serious in China, and transportation is the main source of energy consumption, pollutants, and carbon emissions. This study combined the activity-based analysis method with emission models, and investigated the influence mechanism of people’s activity travel scheduling on transportation energy consumption and emissions on holid...